Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid

L. Lapuerta, N. Chacos, J. R. Falck, H. Jacobson, J. H. Capdevila

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Arachidonic acid is oxidized by the microsomal cytochrome P-450 monooxygenases of rabbit kidney cortex and medulla to products that include W and W-1 alcohols and several epoxyacids. In vivo administration of deoxycorticosterone acetate results in a time dependent and selective induction of the arachidonic acid W/W-1 oxygenase activity of cortex and medulla microsomal fractions (145% and 220% of controls, respectively). Initial segmental analysis shows the presence of an active epoxygenase activity in the isolated rabbit pars recta and its in vitro activation by p-aminohippuric acid.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume295
Issue number4
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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