Repair and regeneration of the respiratory system: Complexity, plasticity, and mechanisms of lung stem cell function

Brigid L M Hogan, Christina E. Barkauskas, Harold A. Chapman, Jonathan A. Epstein, Rajan Jain, Connie C W Hsia, Laura Niklason, Elizabeth Calle, Andrew Le, Scott H. Randell, Jason Rock, Melinda Snitow, Matthew Krummel, Barry R. Stripp, Thiennu Vu, Eric S. White, Jeffrey A. Whitsett, Edward E. Morrisey

Research output: Contribution to journalReview article

346 Scopus citations

Abstract

Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This Review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.

Original languageEnglish (US)
Pages (from-to)123-138
Number of pages16
JournalCell Stem Cell
Volume15
Issue number2
DOIs
StatePublished - Aug 7 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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    Hogan, B. L. M., Barkauskas, C. E., Chapman, H. A., Epstein, J. A., Jain, R., Hsia, C. C. W., Niklason, L., Calle, E., Le, A., Randell, S. H., Rock, J., Snitow, M., Krummel, M., Stripp, B. R., Vu, T., White, E. S., Whitsett, J. A., & Morrisey, E. E. (2014). Repair and regeneration of the respiratory system: Complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell, 15(2), 123-138. https://doi.org/10.1016/j.stem.2014.07.012