@article{2d1857c4580c41f6ac758b2cca9f6ad5,
title = "Repair and regeneration of the respiratory system: Complexity, plasticity, and mechanisms of lung stem cell function",
abstract = "Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This Review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.",
author = "Hogan, {Brigid L M} and Barkauskas, {Christina E.} and Chapman, {Harold A.} and Epstein, {Jonathan A.} and Rajan Jain and Hsia, {Connie C W} and Laura Niklason and Elizabeth Calle and Andrew Le and Randell, {Scott H.} and Jason Rock and Melinda Snitow and Matthew Krummel and Stripp, {Barry R.} and Thiennu Vu and White, {Eric S.} and Whitsett, {Jeffrey A.} and Morrisey, {Edward E.}",
note = "Funding Information: The authors apologize for the omission of any references due to the space constraints of this Review and wish to thank members of their laboratories for input and helpful criticism of this Review. The authors wish to acknowledge the important support from the National Institutes of Health including the Lung Repair and Regeneration Consortium.",
year = "2014",
month = aug,
day = "7",
doi = "10.1016/j.stem.2014.07.012",
language = "English (US)",
volume = "15",
pages = "123--138",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "2",
}