Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

Erin A S Clark, Lisa Mele, Ronald J. Wapner, Catherine Y. Spong, Yoram Sorokin, Alan Peaceman, Jay D. Iams, Kenneth J. Leveno, Margaret Harper, Steve N. Caritis, Brian M. Mercer, John M. Thorp, Susan M. Ramin, Marshall Carpenter, Dwight J. Rouse

Research output: Contribution to journalArticle

Abstract

Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number1
DOIs
StatePublished - Jul 2011

Fingerprint

Adrenal Cortex Hormones
Steroids
Inflammation
Genotype
Interleukin-6
Genes
Odds Ratio
Confidence Intervals
Randomized Controlled Trials

Keywords

  • antenatal corticosteroids
  • gene polymorphisms
  • inflammation
  • interleukin-6
  • neurodevelopmental delay

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2. / Clark, Erin A S; Mele, Lisa; Wapner, Ronald J.; Spong, Catherine Y.; Sorokin, Yoram; Peaceman, Alan; Iams, Jay D.; Leveno, Kenneth J.; Harper, Margaret; Caritis, Steve N.; Mercer, Brian M.; Thorp, John M.; Ramin, Susan M.; Carpenter, Marshall; Rouse, Dwight J.

In: American Journal of Obstetrics and Gynecology, Vol. 205, No. 1, 07.2011.

Research output: Contribution to journalArticle

Clark, EAS, Mele, L, Wapner, RJ, Spong, CY, Sorokin, Y, Peaceman, A, Iams, JD, Leveno, KJ, Harper, M, Caritis, SN, Mercer, BM, Thorp, JM, Ramin, SM, Carpenter, M & Rouse, DJ 2011, 'Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2', American Journal of Obstetrics and Gynecology, vol. 205, no. 1. https://doi.org/10.1016/j.ajog.2011.02.061
Clark, Erin A S ; Mele, Lisa ; Wapner, Ronald J. ; Spong, Catherine Y. ; Sorokin, Yoram ; Peaceman, Alan ; Iams, Jay D. ; Leveno, Kenneth J. ; Harper, Margaret ; Caritis, Steve N. ; Mercer, Brian M. ; Thorp, John M. ; Ramin, Susan M. ; Carpenter, Marshall ; Rouse, Dwight J. / Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 205, No. 1.
@article{f81664f725cf483a92e75adf7f4f6e0b,
title = "Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2",
abstract = "Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95{\%} confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95{\%} confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.",
keywords = "antenatal corticosteroids, gene polymorphisms, inflammation, interleukin-6, neurodevelopmental delay",
author = "Clark, {Erin A S} and Lisa Mele and Wapner, {Ronald J.} and Spong, {Catherine Y.} and Yoram Sorokin and Alan Peaceman and Iams, {Jay D.} and Leveno, {Kenneth J.} and Margaret Harper and Caritis, {Steve N.} and Mercer, {Brian M.} and Thorp, {John M.} and Ramin, {Susan M.} and Marshall Carpenter and Rouse, {Dwight J.}",
year = "2011",
month = "7",
doi = "10.1016/j.ajog.2011.02.061",
language = "English (US)",
volume = "205",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

AU - Clark, Erin A S

AU - Mele, Lisa

AU - Wapner, Ronald J.

AU - Spong, Catherine Y.

AU - Sorokin, Yoram

AU - Peaceman, Alan

AU - Iams, Jay D.

AU - Leveno, Kenneth J.

AU - Harper, Margaret

AU - Caritis, Steve N.

AU - Mercer, Brian M.

AU - Thorp, John M.

AU - Ramin, Susan M.

AU - Carpenter, Marshall

AU - Rouse, Dwight J.

PY - 2011/7

Y1 - 2011/7

N2 - Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.

AB - Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.

KW - antenatal corticosteroids

KW - gene polymorphisms

KW - inflammation

KW - interleukin-6

KW - neurodevelopmental delay

UR - http://www.scopus.com/inward/record.url?scp=79959730625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959730625&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2011.02.061

DO - 10.1016/j.ajog.2011.02.061

M3 - Article

VL - 205

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -