Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis

Shin J. Oh, Yuki Hatanaka, Shoji Hemmi, Angela M. Young, Mia L. Scheufele, Sharon P. Nations, Liang Lu, Gwen C. Claussen, Gil I. Wolfe

Research output: Contribution to journalArticle

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Abstract

To better define electrophysiological abnormalities in myasthenia gravis (MG) patients with muscle-specific tyrosine kinase (MuSK) antibodies (Ab), we compared electrophysiological features of 14 MuSK Ab-positive, 73 acetylcholine receptor antibody (AChR Ab)-positive, and 22 MuSK and AChR Ab-negative (seronegative) patients with generalized disease. Repetitive nerve stimulation (RNS) abnormalities were observed in 86% of MuSK Ab-positive and 82% of AChR Ab-positive patients but in only 55% of seronegative patients. RNS decrements in the orbicularis oculi were more common and severe in the MuSK Ab-positive patients than the other two groups. Single-fiber electromyography (SFEMG) of the extensor digitorum communis was abnormal in 90% of MuSK Ab-positive patients. The high frequency of RNS abnormalities in facial muscles in the MuSK Ab-positive population reflects the propensity for facial muscle involvement in this form of MG and emphasizes the importance of including facial muscles in RNS protocols when evaluating these patients.

Original languageEnglish (US)
Pages (from-to)500-504
Number of pages5
JournalMuscle and Nerve
Volume33
Issue number4
DOIs
StatePublished - Apr 2006

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Facial Muscles
Myasthenia Gravis
Protein-Tyrosine Kinases
Muscles
Antibodies
Cholinergic Receptors
Receptor Protein-Tyrosine Kinases
Electromyography

Keywords

  • Acetylcholine receptor
  • Muscle-specific tyrosine kinase
  • Myasthenia gravis
  • Repetitive nerve stimulation
  • Single-fiber electromyography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Oh, S. J., Hatanaka, Y., Hemmi, S., Young, A. M., Scheufele, M. L., Nations, S. P., ... Wolfe, G. I. (2006). Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis. Muscle and Nerve, 33(4), 500-504. https://doi.org/10.1002/mus.20498

Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis. / Oh, Shin J.; Hatanaka, Yuki; Hemmi, Shoji; Young, Angela M.; Scheufele, Mia L.; Nations, Sharon P.; Lu, Liang; Claussen, Gwen C.; Wolfe, Gil I.

In: Muscle and Nerve, Vol. 33, No. 4, 04.2006, p. 500-504.

Research output: Contribution to journalArticle

Oh, SJ, Hatanaka, Y, Hemmi, S, Young, AM, Scheufele, ML, Nations, SP, Lu, L, Claussen, GC & Wolfe, GI 2006, 'Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis', Muscle and Nerve, vol. 33, no. 4, pp. 500-504. https://doi.org/10.1002/mus.20498
Oh, Shin J. ; Hatanaka, Yuki ; Hemmi, Shoji ; Young, Angela M. ; Scheufele, Mia L. ; Nations, Sharon P. ; Lu, Liang ; Claussen, Gwen C. ; Wolfe, Gil I. / Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis. In: Muscle and Nerve. 2006 ; Vol. 33, No. 4. pp. 500-504.
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