Replacement of the anterior cruciate ligament using a synthetic prosthesis. An evaluation of graft biology in the dog

S. P. Arnoczky, R. F. Warren, J. P. Minei

Research output: Contribution to journalArticle

48 Scopus citations


The ACL of 21 adult mongrel dogs was replaced with a knitted dacron velour prosthesis. The biologic fate of these synthetic grafts was then evaluated at various intervals from 1 to 12 months postoperatively using routine histology and a vascular injection (Spalteholz) technique. Following implantation the knitted dacron prosthesis was encapsulated with a vascular synovial tissue in a manner similar to that observed with autogenous patellar tendon grafts. This revascularization process was followed by a proliferation of fibroblasts throughout the extent of the prosthesis. While the grafts appeared to support a fibrous tissue proliferation in an around the design of the prosthesis, this tissue demonstrated only a random orientation of collagen fibers as a late as 1 year postoperatively. It would appear, therefore, that although the knitted dacron prosthesis is capable of inducing and supporting tissue encapsulation and ingrowth, it does not allow for the functional orientation of this tissue.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalAmerican Journal of Sports Medicine
Issue number1
Publication statusPublished - 1986


ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this