Replication of the LINGO1 gene association with essential tremor in a North American population

Lorraine N. Clark, Naeun Park, Sergey Kisselev, Eileen Rios, Joseph H. Lee, Elan D. Louis

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

A marker in the LINGO1 gene, rs9652490, showing significant genome-wide association with essential tremor (ET), was recently reported in an Icelandic population. To replicate this association in an independent population from North America, we genotyped 15 SNPs in the LINGO1 gene in 257 Caucasian ET cases (definite, probable or possible) and 265 controls enrolled in an epidemiological study at Columbia University. We observed a marginally significant association with allele G of the marker rs9652490 (P=0.0569, odds ratio (OR)1.33). However, for definite or probable ET, rs9652490 was significantly associated with ET (P=0.03, OR1.41). Our subsequent analysis of early-onset ET (age at onset <40 years) revealed that three SNPs, rs177008, rs13313467 and rs8028808, were significantly associated with ET (P=0.028, OR=1.52; P=0.0238, OR1.54; and P=0.0391, OR=1.55, respectively). These three SNPs represent a 2.3 kb haplotype. Finally, a meta-analysis of three published studies confirms allelic association with rs9652490 and two adjacent SNPs. Our study independently confirms that the LINGO1 gene is a risk factor for ET in a Caucasian population in North America, and further shows that those with early-onset ET are likely to be at high risk.

Original languageEnglish (US)
Pages (from-to)838-843
Number of pages6
JournalEuropean Journal of Human Genetics
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Keywords

  • Association
  • Essential tremor
  • LINGO1
  • Risk factor

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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