Representations of Novelty and Familiarity in a Mushroom Body Compartment

Daisuke Hattori, Yoshinori Aso, Kurtis J. Swartz, Gerald M. Rubin, L. F. Abbott, Richard Axel

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Animals exhibit a behavioral response to novel sensory stimuli about which they have no prior knowledge. We have examined the neural and behavioral correlates of novelty and familiarity in the olfactory system of Drosophila. Novel odors elicit strong activity in output neurons (MBONs) of the α′3 compartment of the mushroom body that is rapidly suppressed upon repeated exposure to the same odor. This transition in neural activity upon familiarization requires odor-evoked activity in the dopaminergic neuron innervating this compartment. Moreover, exposure of a fly to novel odors evokes an alerting response that can also be elicited by optogenetic activation of α′3 MBONs. Silencing these MBONs eliminates the alerting behavior. These data suggest that the α′3 compartment plays a causal role in the behavioral response to novel and familiar stimuli as a consequence of dopamine-mediated plasticity at the Kenyon cell-MBONα′3 synapse.

Original languageEnglish (US)
Pages (from-to)956-969.e17
JournalCell
Volume169
Issue number5
DOIs
StatePublished - May 18 2017
Externally publishedYes

    Fingerprint

Keywords

  • alerting response
  • dopamine
  • Drosophila melanogaster
  • mushroom body
  • novelty and familiarity
  • olfactory learning and memory
  • repetition suppression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hattori, D., Aso, Y., Swartz, K. J., Rubin, G. M., Abbott, L. F., & Axel, R. (2017). Representations of Novelty and Familiarity in a Mushroom Body Compartment. Cell, 169(5), 956-969.e17. https://doi.org/10.1016/j.cell.2017.04.028