Requirement for CD44 in activated T cell extravasation into an inflammatory site

Heather C. DeGrendele, Pila Estess, Mark H. Siegelman

Research output: Contribution to journalArticle

445 Citations (Scopus)

Abstract

Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine Vβ8+ T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of Vβ8+ cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.

Original languageEnglish (US)
Pages (from-to)672-675
Number of pages4
JournalScience
Volume278
Issue number5338
DOIs
StatePublished - Oct 24 1997

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Leukocytes
T-Lymphocytes
Superantigens
Peritoneum
Peritoneal Cavity
Cell Movement
Endothelial Cells
Lymph Nodes
Lymphocytes
Ligands

ASJC Scopus subject areas

  • General

Cite this

Requirement for CD44 in activated T cell extravasation into an inflammatory site. / DeGrendele, Heather C.; Estess, Pila; Siegelman, Mark H.

In: Science, Vol. 278, No. 5338, 24.10.1997, p. 672-675.

Research output: Contribution to journalArticle

DeGrendele, Heather C. ; Estess, Pila ; Siegelman, Mark H. / Requirement for CD44 in activated T cell extravasation into an inflammatory site. In: Science. 1997 ; Vol. 278, No. 5338. pp. 672-675.
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