TY - JOUR
T1 - Requirement for CD44 in activated T cell extravasation into an inflammatory site
AU - DeGrendele, Heather C.
AU - Estess, Pila
AU - Siegelman, Mark H.
PY - 1997/10/24
Y1 - 1997/10/24
N2 - Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine Vβ8+ T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of Vβ8+ cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.
AB - Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine Vβ8+ T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of Vβ8+ cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.
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U2 - 10.1126/science.278.5338.672
DO - 10.1126/science.278.5338.672
M3 - Article
C2 - 9381175
AN - SCOPUS:0030690228
SN - 0036-8075
VL - 278
SP - 672
EP - 675
JO - Science
JF - Science
IS - 5338
ER -