Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila

Brenda Lilly, Bin Zhao, Gogineni Ranganayakulu, Bruce M. Paterson, Robert A. Schulz, Eric N. Olson

Research output: Contribution to journalArticle

402 Scopus citations

Abstract

Members of the myocyte enhancer binding factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors are expressed in the skeletal, cardiac, and smooth muscle lineages of vertebrate and Drosophila embryos. These factors bind an adenine-thymidine-rich DNA sequence associated with muscle-specific genes. The function of MEF2 was determined by generating a loss-of-function of the single mef2 gene in Drosophila (D-mef2). In loss-of-function embryos; somatic, cardiac, and visceral muscle cells did not differentiate, but myoblasts were normally specified and positioned. These results demonstrate that different muscle cell, types share a common myogenic differentiation program controlled by MEF2.

Original languageEnglish (US)
Pages (from-to)688-693
Number of pages6
JournalScience
Volume267
Issue number5198
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

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    Lilly, B., Zhao, B., Ranganayakulu, G., Paterson, B. M., Schulz, R. A., & Olson, E. N. (1995). Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science, 267(5198), 688-693. https://doi.org/10.1126/science.7839146