TY - JOUR
T1 - Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
AU - Lilly, Brenda
AU - Zhao, Bin
AU - Ranganayakulu, Gogineni
AU - Paterson, Bruce M.
AU - Schulz, Robert A.
AU - Olson, Eric N.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Members of the myocyte enhancer binding factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors are expressed in the skeletal, cardiac, and smooth muscle lineages of vertebrate and Drosophila embryos. These factors bind an adenine-thymidine-rich DNA sequence associated with muscle-specific genes. The function of MEF2 was determined by generating a loss-of-function of the single mef2 gene in Drosophila (D-mef2). In loss-of-function embryos; somatic, cardiac, and visceral muscle cells did not differentiate, but myoblasts were normally specified and positioned. These results demonstrate that different muscle cell, types share a common myogenic differentiation program controlled by MEF2.
AB - Members of the myocyte enhancer binding factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors are expressed in the skeletal, cardiac, and smooth muscle lineages of vertebrate and Drosophila embryos. These factors bind an adenine-thymidine-rich DNA sequence associated with muscle-specific genes. The function of MEF2 was determined by generating a loss-of-function of the single mef2 gene in Drosophila (D-mef2). In loss-of-function embryos; somatic, cardiac, and visceral muscle cells did not differentiate, but myoblasts were normally specified and positioned. These results demonstrate that different muscle cell, types share a common myogenic differentiation program controlled by MEF2.
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U2 - 10.1126/science.7839146
DO - 10.1126/science.7839146
M3 - Article
C2 - 7839146
AN - SCOPUS:0028917564
SN - 0036-8075
VL - 267
SP - 688
EP - 693
JO - Science
JF - Science
IS - 5198
ER -