Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development

R. N. Freiman; S. R. Albright; S. Zheng; W. C. Sha; Robert E Hammer; R. Tjian

doi:10.1126/science.1061935

Requirement of tissue-selective TBP-associated factor TAF_II105 in ovarian development

R. N. Freiman, S. R. Albright, S. Zheng, W. C. Sha, Robert E Hammer, R. Tjian

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Abstract

Transcription factor TFIID, composed of TBP and TAF_II subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAF_II105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAF_II105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAF_II105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAF_II105-deficient ovaries. Together, these studies suggest that TAF_II105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAF_II105 as a cell type-specific component of the mammalian transcriptional machinery.

Original language	English (US)
Pages (from-to)	2084-2087
Number of pages	4
Journal	Science
Volume	293
Issue number	5537
DOIs	https://doi.org/10.1126/science.1061935
State	Published - Sep 14 2001

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title = "Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development",

abstract = "Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.",

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AU - Freiman, R. N.

AU - Albright, S. R.

AU - Zheng, S.

AU - Sha, W. C.

AU - Hammer, Robert E

AU - Tjian, R.

PY - 2001/9/14

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N2 - Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.

AB - Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.

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Requirement of tissue-selective TBP-associated factor TAF_II105 in ovarian development

Abstract

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