Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop

Timothy M. Block, Harvey Alter, Nathaniel Brown, Alan Brownstein, Carol Brosgart, Kyong Mi Chang, Pei Jer Chen, Chari Cohen, Hashem El-Serag, Jordan Feld, Robert Gish, Jeffrey Glenn, Tim F. Greten, Juo Tao Guo, Yujin Hoshida, Kris V. Kowdley, Wenhui Li, Anna S. Lok, Brian McMahon, Anand MehtaRobert Perrillo, Charles M. Rice, Jo Ann Rinaudo, Raymond F. Schinazi, Kirti Shetty

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In early 2017, the Hepatitis B Foundation invited 30 experts in the fields of hepatitis B and liver cancer research to identify projects they deemed important to the goal of finding a cure for chronic hepatitis B and D and the diseases with which these viral infections are associated. They were also asked to identify general categories of research and to prioritize sub-project topics within those areas. The experts generally agreed on broadly defined areas of research, but there was usually little difference between the highest and lowest scoring projects; for the most part, all programs described in this document were considered valuable and necessary. An executive summary of this discussion was recently published (Alter et al., Hepatology 2017). The present manuscript reports the areas of research identified by the workshop participants, provides a brief rationale for their selection, and attempts to express differences among the priorities assigned to each area of research, when such distinctions were expressed.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalAntiviral Research
Volume150
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • Antiviral therapy
  • Hepatitis B
  • Hepatitis D
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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    Block, T. M., Alter, H., Brown, N., Brownstein, A., Brosgart, C., Chang, K. M., Chen, P. J., Cohen, C., El-Serag, H., Feld, J., Gish, R., Glenn, J., Greten, T. F., Guo, J. T., Hoshida, Y., Kowdley, K. V., Li, W., Lok, A. S., McMahon, B., ... Shetty, K. (2018). Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop. Antiviral Research, 150, 93-100. https://doi.org/10.1016/j.antiviral.2017.12.006