Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia

Srinevas K. Reddy, Priya S. Kishnani, Jennifer A. Sullivan, Dwight D. Koeberl, Dev M. Desai, Michael A. Skinner, Henry E. Rice, Bryan M. Clary

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Background/Aims: Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing. The objective of this retrospective study is to assess the safety and effectiveness of HCA resection in GSD Ia patients. Methods: Clinicopathologic, peri-operative, and long-term data were reviewed from patients who underwent HCA resection. Comparisons were made with Fisher's exact, Mann-Whitney U, and log-rank tests; survival was estimated with Kaplan-Meier analysis. Results: From 1998 to 2006, 38 patients underwent HCA resection. Seven (22%) had GSD Ia. Post-operative mortality occurred in one GSD Ia patient. GSD Ia patients had greater morbidity (86% vs. 20%) and shorter time to adenoma progression (median 23 months vs. not yet reached) after partial hepatectomy compared to the general population (p < 0.05). Six GSD Ia patients had no evidence of HCC and recovered after resection without long-term morbidity. Three GSD Ia patients underwent liver transplantation 77, 32, and 23 months after adenoma resection. Conclusions: Despite substantial morbidity, partial hepatectomy is feasible in GSD Ia patients and is an effective intermediate step in the prevention of HCC until definitive treatment with liver transplantation.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalJournal of Hepatology
Volume47
Issue number5
DOIs
StatePublished - Nov 1 2007

Keywords

  • Glycogen storage disease type Ia
  • Hepatic resection
  • Hepatocellular adenoma
  • Liver transplantation

ASJC Scopus subject areas

  • Hepatology

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    Reddy, S. K., Kishnani, P. S., Sullivan, J. A., Koeberl, D. D., Desai, D. M., Skinner, M. A., Rice, H. E., & Clary, B. M. (2007). Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia. Journal of Hepatology, 47(5), 658-663. https://doi.org/10.1016/j.jhep.2007.05.012