Resident viruses and their interactions with the immune system

Breck A. Duerkop; Lora V. Hooper

doi:10.1038/ni.2614

Resident viruses and their interactions with the immune system

Breck A. Duerkop, Lora V. Hooper

Research output: Contribution to journal › Review article › peer-review

213 Scopus citations

Abstract

The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.

Original language	English (US)
Pages (from-to)	654-659
Number of pages	6
Journal	Nature immunology
Volume	14
Issue number	7
DOIs	https://doi.org/10.1038/ni.2614
State	Published - Jul 2013

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/ni.2614

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title = "Resident viruses and their interactions with the immune system",

abstract = "The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.",

author = "Duerkop, {Breck A.} and Hooper, {Lora V.}",

note = "Funding Information: Supported by a Ruth L. Kirschstein National Research Service Award F32 DK089718 (to B.A.D.), The Howard Hughes Medical Institute (to L.V.H.), US National Institutes of Health grant R01 DK070855 (to L.V.H.) and a Burroughs Wellcome Foundation Investigators in the Pathogenesis of Infectious Diseases award (to L.V.H.).",

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Resident viruses and their interactions with the immune system

Abstract

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