TY - JOUR
T1 - Residential proximity to waste sites and industrial facilities and chromosomal anomalies in offspring
AU - Brender, Jean D.
AU - Zhan, F. Benjamin
AU - Langlois, Peter H.
AU - Suarez, Lucina
AU - Scheuerle, Angela
N1 - Funding Information:
This study was supported through the cooperative agreement U50/CCU613232 from the Centers for Disease Control and Prevention and contract 7547547549 from the Texas Department of State Health Services Center for Birth Defects Research and Prevention. The authors thank Wendy Marckwardt, Texas State University for her assistance in abstracting environmental data, Ionara Delima, Texas State University for geocoding industrial and maternal addresses, and Zunera Gilani, Texas Department of State Health Services for assistance with the birth files. They also thank Yaowen Han, Texas State University for providing computer programming expertise in the file linkages.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2008/3/12
Y1 - 2008/3/12
N2 - A few studies have found chromosomal anomalies in offspring associated with a maternal residence near waste sites, but did not examine the effect of living near industrial facilities, and most combined specific anomalies into heterogeneous groups. With a case-control study design, we investigated whether maternal residential proximity to hazardous waste sites or industrial facilities with chemical air emissions was associated with chromosomal anomalies in births. Maternal residences of 2099 Texas births with chromosomal anomalies and 4368 control births without documented malformations were related to boundaries of hazardous waste sites and street addresses of industrial facilities through geographic information systems. With adjustment for maternal age, race/ethnicity, and education, maternal residence within 1 mile of a hazardous waste site (relative to farther away) was not associated with chromosomal anomalies in offspring except for Klinefelter variants among Hispanic births (odds ratios (OR) 7.9, 95% confidence interval (CI) 1.1-42.4). Women 35 years or older who lived within 1 mile of industries with emissions of heavy metals were two times more likely (95% CI 1.1-4.1) than women living farther away to have offspring with chromosomal anomalies including trisomies 13, 18, or 21 or sex chromosome abnormalities. Among women 40 years or older, maternal residence within a mile of industries with solvent emissions was associated with chromosomal anomalies in births (OR 4.8, 95% CI 1.2-42.8). Study findings suggest some relation between residential proximity to industries with emissions of solvents or heavy metals and chromosomal anomalies in births to older mothers.
AB - A few studies have found chromosomal anomalies in offspring associated with a maternal residence near waste sites, but did not examine the effect of living near industrial facilities, and most combined specific anomalies into heterogeneous groups. With a case-control study design, we investigated whether maternal residential proximity to hazardous waste sites or industrial facilities with chemical air emissions was associated with chromosomal anomalies in births. Maternal residences of 2099 Texas births with chromosomal anomalies and 4368 control births without documented malformations were related to boundaries of hazardous waste sites and street addresses of industrial facilities through geographic information systems. With adjustment for maternal age, race/ethnicity, and education, maternal residence within 1 mile of a hazardous waste site (relative to farther away) was not associated with chromosomal anomalies in offspring except for Klinefelter variants among Hispanic births (odds ratios (OR) 7.9, 95% confidence interval (CI) 1.1-42.4). Women 35 years or older who lived within 1 mile of industries with emissions of heavy metals were two times more likely (95% CI 1.1-4.1) than women living farther away to have offspring with chromosomal anomalies including trisomies 13, 18, or 21 or sex chromosome abnormalities. Among women 40 years or older, maternal residence within a mile of industries with solvent emissions was associated with chromosomal anomalies in births (OR 4.8, 95% CI 1.2-42.8). Study findings suggest some relation between residential proximity to industries with emissions of solvents or heavy metals and chromosomal anomalies in births to older mothers.
KW - Chromosomal anomalies
KW - Geographic information system
KW - Hazardous waste sites
KW - Industrial pollution
KW - Residential exposure
UR - http://www.scopus.com/inward/record.url?scp=39049132861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049132861&partnerID=8YFLogxK
U2 - 10.1016/j.ijheh.2007.02.009
DO - 10.1016/j.ijheh.2007.02.009
M3 - Article
C2 - 17470415
AN - SCOPUS:39049132861
SN - 1438-4639
VL - 211
SP - 50
EP - 58
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
IS - 1-2
ER -