Residual Effects of THC via Novel Measures of Brain Perfusion and Metabolism in a Large Group of Chronic Cannabis Users

Francesca M. Filbey, Sina Aslan, Hanzhang Lu, Shin Lei Peng

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Given the known vascular effects of cannabis, this study examined the neurophysiological factors that may affect studies of brain activity in cannabis users. We conducted a systematic evaluation in 72 h abstinent, chronic cannabis users (N=74) and nonusing controls (N=101) to determine the association between prolonged cannabis use and the following neurophysiological indicators: (1) global and regional resting cerebral blood flow (CBF), (2) oxygen extraction fraction (OEF), and (3) cerebral metabolic rate of oxygen (CMRO2). We found that cannabis users had greater global OEF and CMRO2 compared with nonusers. Regionally, we found higher CBF in the right pallidum/putamen of the cannabis users compared with nonusers. Global resting CBF and regional CBF of right superior frontal cortex correlated positively with creatinine-normalized Δ9-tetrahydrocannabinol (THC) levels. These findings demonstrate residual effects of cannabis use whereby global and regional brain metabolism are altered in those with prolonged cannabis exposure. These neurophysiological alterations should be considered in both research and clinical applications.Neuropsychopharmacology advance online publication, 22 March 2017; doi:10.1038/npp.2017.44.

Original languageEnglish (US)
JournalNeuropsychopharmacology
DOIs
StateAccepted/In press - Mar 22 2017

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Dronabinol
Cannabis
Cerebrovascular Circulation
Perfusion
Brain
Oxygen
Globus Pallidus
Putamen
Regional Blood Flow
Frontal Lobe
Blood Vessels
Publications
Creatinine
Research

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Residual Effects of THC via Novel Measures of Brain Perfusion and Metabolism in a Large Group of Chronic Cannabis Users. / Filbey, Francesca M.; Aslan, Sina; Lu, Hanzhang; Peng, Shin Lei.

In: Neuropsychopharmacology, 22.03.2017.

Research output: Contribution to journalArticle

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