Resistance of interleukin-1β-deficient mice to fatal sindbis virus encephalitis

Xiao Huan Liang, James E. Goldman, Hui Hui Jiang, Beth Levine

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Interleukin-1β (IL-1β) concentrations are frequently elevated in central nervous system (CNS) viral infections, but the pathophysiologic significance of such elevations is not known. To examine the role of IL-1β in CNS viral pathogenesis, we compared the natural histories of IL-1β- deficient and wild-type 129 SV(ev) mice infected with a neurovirulent viral strain, neuroadapted Sindbis virus (NSV). We found that the incidence of severe paralysis and death was markedly decreased in NSV-infected IL-1β(-/- ) mice compared to NSV-infected wild-type mice (4 versus 88%, P < 0.001). Despite this marked difference in clinical outcome, no differences in numbers of apoptotic cells or presence of histopathologic lesions in the brains of moribund wild-type mice and those of clinically healthy IL-1β(-/-) mice could be detected. These results suggest that IL-1̄ deficiency is protective against fatal Sindbis virus infection by a mechanism that does not involve resistance to CNS virus-induced apoptosis or histopathology.

Original languageEnglish (US)
Pages (from-to)2563-2567
Number of pages5
JournalJournal of Virology
Volume73
Issue number3
StatePublished - 1999

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Sindbis virus
Sindbis Virus
interleukin-1
Encephalitis
encephalitis
Interleukin-1
mice
central nervous system
Central Nervous System Viral Diseases
Central Nervous System
paralysis
Virus Diseases
Natural History
natural history
Paralysis
lesions (animal)
infection
histopathology
pathogenesis
apoptosis

ASJC Scopus subject areas

  • Immunology

Cite this

Resistance of interleukin-1β-deficient mice to fatal sindbis virus encephalitis. / Liang, Xiao Huan; Goldman, James E.; Jiang, Hui Hui; Levine, Beth.

In: Journal of Virology, Vol. 73, No. 3, 1999, p. 2563-2567.

Research output: Contribution to journalArticle

Liang, XH, Goldman, JE, Jiang, HH & Levine, B 1999, 'Resistance of interleukin-1β-deficient mice to fatal sindbis virus encephalitis', Journal of Virology, vol. 73, no. 3, pp. 2563-2567.
Liang, Xiao Huan ; Goldman, James E. ; Jiang, Hui Hui ; Levine, Beth. / Resistance of interleukin-1β-deficient mice to fatal sindbis virus encephalitis. In: Journal of Virology. 1999 ; Vol. 73, No. 3. pp. 2563-2567.
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