Resistance to non-strain-specific variant tumor cells by h-2 allogeneic mice receiving strain-specific cells12

James Forman, Melvin M. Ketchel

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A non-strain-specific (NSS) variant of the L5178 tumor line could grow in H-2 allogeneic hosts, whereas a strain-specific (SS) subline could not. When NSS and SS cells were injected simultaneously into H-2 allogeneic hosts, both were rejected. This effect was not seen in irradiated or non-H-2 allogeneic mice. The concentration of alloantigenic determinants H-2.3 and H-2.4 did not differ in the NSS and SS tumor cells. Apparently, although both SS and NSS cells had equivalent amounts of antigen on their surfaces and were susceptible to the homograft reaction in vivo, NSS cells could not sensitize H-2 allogeneic mice so that they could reject the tumor.

Original languageEnglish (US)
Pages (from-to)933-939
Number of pages7
JournalJournal of the National Cancer Institute
Volume48
Issue number4
DOIs
StatePublished - Apr 1972

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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