A non-strain-specific (NSS) variant of the L5178 tumor line could grow in H-2 allogeneic hosts, whereas a strain-specific (SS) subline could not. When NSS and SS cells were injected simultaneously into H-2 allogeneic hosts, both were rejected. This effect was not seen in irradiated or non-H-2 allogeneic mice. The concentration of alloantigenic determinants H-2.3 and H-2.4 did not differ in the NSS and SS tumor cells. Apparently, although both SS and NSS cells had equivalent amounts of antigen on their surfaces and were susceptible to the homograft reaction in vivo, NSS cells could not sensitize H-2 allogeneic mice so that they could reject the tumor.
ASJC Scopus subject areas
- Cancer Research