Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Tamia Harris-Tryon, Sureka Gattu, Daniel C Propheter, Zheng Kuang, Shai Bel, Kelly A. Ruhn, Andrew L. Chara, Marshall Edwards, Chenlu Zhang, Jay Hyun Jo, Prithvi Raj, Christos C. Zouboulis, Heidi H. Kong, Julia A. Segre, Lora V Hooper

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Vitamin A regulates skin immunity via unknown mechanisms. Harris et al. show that RELMα is an antimicrobial protein expressed by epidermal cells that shapes resident skin bacterial communities and limits skin infection. RELMα is induced by dietary vitamin A and mediates vitamin-A-dependent resistance to skin infection.

Original languageEnglish (US)
Pages (from-to)777-788.e8
JournalCell Host and Microbe
Volume25
Issue number6
DOIs
StatePublished - Jun 12 2019

    Fingerprint

Keywords

  • antimicrobial protein
  • bacteria
  • innate immunity
  • microbiome
  • skin
  • skin infection
  • vitamin A

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Harris-Tryon, T., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A., & Hooper, L. V. (2019). Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin. Cell Host and Microbe, 25(6), 777-788.e8. https://doi.org/10.1016/j.chom.2019.04.004