Respiratory effects of a patent ductus arteriosus in premature newborn lambs

J. J. Perez Fontan, R. I. Clyman, F. Mauray, M. A. Heymann, C. Roman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We examined the respiratory effects of a patent ductus arteriosus in 29 premature lambs (131-135 days gestational age) after infiltrating the ductal wall with formaldehyde solution (Formalin) and placing a snare around the ductus to regulate its patency. The lambs were given sheep surfactant, paralyzed, and mechanically ventilated at birth. We first compared 8 lambs with open ductus and 13 lambs with closed ductus during the 12 h after birth. Although lambs with open ductus had greater pulmonary blood flow (301 ± 36 vs. 188 ± ml·min-1·kg-1, mean ± SE, at 12 h of age) and mean pulmonary arterial (44 ± 3 vs. 33 ± 2 mmHg) and left ventricular end-diastolic (6 ± 0.6 vs. 4 ± 0.7 mmHg) pressures, we found no differences in dynamic respiratory compliance (Cdyn = 0.55 ± 0.07 vs. 0.55 ± 0.03 ml·cmH2O-1·kg-1), midtidal volume resistance (62 ± 5 x 10-3 vs. 62 ± 7 x 10-3 cmH2O·ml-1·s), or functional residual capacity (FRC = 27 ± 3 vs. 26 ± 2 ml·kg-1). Alveolar-arterial PO2 difference was lower in the lambs with open ductus (238 ± 65 vs. 362 ± 37 Torr). Next, we challenged eight lambs with two separate saline infusions (50 ml·kg-1 over 3 min), each given with the ductus alternately closed or open. When the ductus was closed, FRC was unchanged, but Cdyn increased by 18% immediately after the infusion. When the ductus was open, FRC decreased by 16% and Cdyn decreased by 12%. We conclude that the premature lamb is surprisingly resistant to changes in respiratory function from ductal patency during the immediate neonatal period.

Original languageEnglish (US)
Pages (from-to)2315-2324
Number of pages10
JournalJournal of Applied Physiology
Volume63
Issue number6
StatePublished - 1987

Fingerprint

Patent Ductus Arteriosus
Parturition
Functional Residual Capacity
Lung
Surface-Active Agents
Formaldehyde
Gestational Age
Compliance
Sheep
Pressure

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Perez Fontan, J. J., Clyman, R. I., Mauray, F., Heymann, M. A., & Roman, C. (1987). Respiratory effects of a patent ductus arteriosus in premature newborn lambs. Journal of Applied Physiology, 63(6), 2315-2324.

Respiratory effects of a patent ductus arteriosus in premature newborn lambs. / Perez Fontan, J. J.; Clyman, R. I.; Mauray, F.; Heymann, M. A.; Roman, C.

In: Journal of Applied Physiology, Vol. 63, No. 6, 1987, p. 2315-2324.

Research output: Contribution to journalArticle

Perez Fontan, JJ, Clyman, RI, Mauray, F, Heymann, MA & Roman, C 1987, 'Respiratory effects of a patent ductus arteriosus in premature newborn lambs', Journal of Applied Physiology, vol. 63, no. 6, pp. 2315-2324.
Perez Fontan, J. J. ; Clyman, R. I. ; Mauray, F. ; Heymann, M. A. ; Roman, C. / Respiratory effects of a patent ductus arteriosus in premature newborn lambs. In: Journal of Applied Physiology. 1987 ; Vol. 63, No. 6. pp. 2315-2324.
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