Respiratory plasticity in response to changes in oxygen supply and demand

Ryan W. Bavis, Frank L. Powell, Aidan Bradford, Connie C W Hsia, Juha E. Peltonen, Jorge Soliz, Bettina Zeis, Elizabeth K. Fergusson, Zhenxing Fu, Max Gassmann, Cindy B. Kim, Jana Maurer, Michelle McGuire, Brooke M. Miller, Ken D. O'Halloran, Rdiger J. Paul, Stephen G. Reid, Heikki K. Rusko, Heikki O. Tikkanen, Katherine A. Wilkinson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aerobic organisms maintain O2 homeostasis by responding to changes in O2 supply and demand in both short and long time domains. In this review, we introduce several specific examples of respiratory plasticity induced by chronic changes in O2 supply (environmental hypoxia or hyperoxia) and demand (exercise-induced and temperature-induced changes in aerobic metabolism). These studies reveal that plasticity occurs throughout the respiratory system, including modifications to the gas exchanger, respiratory pigments, respiratory muscles, and the neural control systems responsible for ventilating the gas exchanger. While some of these responses appear appropriate (e.g., increases in lung surface area, blood O2 capacity, and pulmonary ventilation in hypoxia), other responses are potentially harmful (e.g., increased muscle fatigability). Thus, it may be difficult to predict whole-animal performance based on the plasticity of a single system. Moreover, plastic responses may differ quantitatively and qualitatively at different developmental stages. Much of the current research in this field is focused on identifying the cellular and molecular mechanisms underlying respiratory plasticity. These studies suggest that a few key molecules, such as hypoxia inducible factor (HIF) and erythropoietin, may be involved in the expression of diverse forms of plasticity within and across species. Studying the various ways in which animals respond to respiratory challenges will enable a better understanding of the integrative response to chronic changes in O2 supply and demand.

Original languageEnglish (US)
Pages (from-to)532-551
Number of pages20
JournalIntegrative and Comparative Biology
Volume47
Issue number4
DOIs
StatePublished - Oct 2007

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supply balance
hypoxia
oxygen
lungs
gases
hyperoxia
erythropoietin
muscles
animal performance
respiratory system
surface area
homeostasis
exercise
plastics
pigments
developmental stages
metabolism
blood
organisms
animals

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Bavis, R. W., Powell, F. L., Bradford, A., Hsia, C. C. W., Peltonen, J. E., Soliz, J., ... Wilkinson, K. A. (2007). Respiratory plasticity in response to changes in oxygen supply and demand. Integrative and Comparative Biology, 47(4), 532-551. https://doi.org/10.1093/icb/icm070

Respiratory plasticity in response to changes in oxygen supply and demand. / Bavis, Ryan W.; Powell, Frank L.; Bradford, Aidan; Hsia, Connie C W; Peltonen, Juha E.; Soliz, Jorge; Zeis, Bettina; Fergusson, Elizabeth K.; Fu, Zhenxing; Gassmann, Max; Kim, Cindy B.; Maurer, Jana; McGuire, Michelle; Miller, Brooke M.; O'Halloran, Ken D.; Paul, Rdiger J.; Reid, Stephen G.; Rusko, Heikki K.; Tikkanen, Heikki O.; Wilkinson, Katherine A.

In: Integrative and Comparative Biology, Vol. 47, No. 4, 10.2007, p. 532-551.

Research output: Contribution to journalArticle

Bavis, RW, Powell, FL, Bradford, A, Hsia, CCW, Peltonen, JE, Soliz, J, Zeis, B, Fergusson, EK, Fu, Z, Gassmann, M, Kim, CB, Maurer, J, McGuire, M, Miller, BM, O'Halloran, KD, Paul, RJ, Reid, SG, Rusko, HK, Tikkanen, HO & Wilkinson, KA 2007, 'Respiratory plasticity in response to changes in oxygen supply and demand', Integrative and Comparative Biology, vol. 47, no. 4, pp. 532-551. https://doi.org/10.1093/icb/icm070
Bavis, Ryan W. ; Powell, Frank L. ; Bradford, Aidan ; Hsia, Connie C W ; Peltonen, Juha E. ; Soliz, Jorge ; Zeis, Bettina ; Fergusson, Elizabeth K. ; Fu, Zhenxing ; Gassmann, Max ; Kim, Cindy B. ; Maurer, Jana ; McGuire, Michelle ; Miller, Brooke M. ; O'Halloran, Ken D. ; Paul, Rdiger J. ; Reid, Stephen G. ; Rusko, Heikki K. ; Tikkanen, Heikki O. ; Wilkinson, Katherine A. / Respiratory plasticity in response to changes in oxygen supply and demand. In: Integrative and Comparative Biology. 2007 ; Vol. 47, No. 4. pp. 532-551.
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