Response in relation to baseline anxiety levels in major depressive disorder treated with bupropion sustained release or sertraline

A. John Rush, Madhukar H. Trivedi, Thomas J. Carmody, Rafe M J Donahue, Trisha L. Houser, Carolyn Bolden-Watson, Sharyn R. Batey, John A. Ascher, Alan Metz

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Our objective was to determine if pretreatment anxiety levels were associated with preferential response to bupropion sustained release (n = 122) or sertraline (n = 126) during a 16-week randomized acute phase treatment study. Both agents had comparable antidepressant activity, and comparable anxiolytic effects using the intent-to-treat sample. Baseline anxiety levels were not related to antidepressant efficacy, and they did not differentiate responders to each agent. Time to clinically significant anxiolysis did not differentiate between treatment groups or between responders to each agent. These results contradict the commonly held, but unsubstantiated, belief that in clinically depressed anxious patients, serotonergic antidepressants are especially anxiolytic and that such patients preferentially benefit from the antidepressant or anxiolytic effects of selective serotonin reuptake inhibitors. Thus, the clinical decision to select between these two agents when treating depressed outpatients cannot rest on either levels of pretreatment anxiety or on anticipation of more rapid or more complete anxiolysis.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalNeuropsychopharmacology
Volume25
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Anxiolysis
  • Bupropion SR
  • Major depressive disorder
  • Pretreatment anxiety
  • Retrospective analysis
  • Sertraline

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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