Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain)

Fnu Nagajyothi; Mahalia S. Desruisseaux; Fabiana S. MacHado; Rajendra Upadhya; Dazhi Zhao; Gary J. Schwartz; Mauro M. Teixeira; Chris Albanese; Michael P. Lisanti; Streamson C. Chua; Louis M. Weiss; Philipp E. Scherer; Herbert B. Tanowitz

doi:10.1093/infdis/jir840

Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain)

Fnu Nagajyothi, Mahalia S. Desruisseaux, Fabiana S. MacHado, Rajendra Upadhya, Dazhi Zhao, Gary J. Schwartz, Mauro M. Teixeira, Chris Albanese, Michael P. Lisanti, Streamson C. Chua, Louis M. Weiss, Philipp E. Scherer, Herbert B. Tanowitz

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Abstract

Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor γ were increased in WAT, whereas protein and mRNA levels of adiponectin were significantly reduced in BAT and WAT. The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection.

Original language	English (US)
Pages (from-to)	830-840
Number of pages	11
Journal	Journal of Infectious Diseases
Volume	205
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jir840
State	Published - Mar 1 2012

ASJC Scopus subject areas

General Medicine

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Nagajyothi, F., Desruisseaux, M. S., MacHado, F. S., Upadhya, R., Zhao, D., Schwartz, G. J., Teixeira, M. M., Albanese, C., Lisanti, M. P., Chua, S. C., Weiss, L. M., Scherer, P. E., & Tanowitz, H. B. (2012). Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain). Journal of Infectious Diseases, 205(5), 830-840. https://doi.org/10.1093/infdis/jir840

@article{698cde0b12304c91a55885c570f9da32,

title = "Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain)",

abstract = "Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor γ were increased in WAT, whereas protein and mRNA levels of adiponectin were significantly reduced in BAT and WAT. The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection.",

author = "Fnu Nagajyothi and Desruisseaux, {Mahalia S.} and MacHado, {Fabiana S.} and Rajendra Upadhya and Dazhi Zhao and Schwartz, {Gary J.} and Teixeira, {Mauro M.} and Chris Albanese and Lisanti, {Michael P.} and Chua, {Streamson C.} and Weiss, {Louis M.} and Scherer, {Philipp E.} and Tanowitz, {Herbert B.}",

note = "Funding Information: Financial support. This work was supported in part by the National Institutes of Health (AI-076248, HL-73732, AI-06538 to H. B. T., DK55758, CA112023, and RC1 DK086629 to P. E. S., P60-DK020541 to S. C. C. and G. J. S., 1 R03-TW006857 FIRCA to M. M. T. and H. B. T.); Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (to F. S. M. and M. M. T.); and Fundaxc{\~a}o de Amparo {\`a} Pesquisa do Estado de Minas Gerais (to F. S. M.). This work was also supported by a pilot grant from the Diabetes Research and Training Center, Albert Einstein College of Medicine. Potential conflicts of interest. All authors: No reported conflicts.",

year = "2012",

month = mar,

day = "1",

doi = "10.1093/infdis/jir840",

language = "English (US)",

volume = "205",

pages = "830--840",

journal = "Journal of Infectious Diseases",

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T1 - Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain)

AU - Nagajyothi, Fnu

AU - Desruisseaux, Mahalia S.

AU - MacHado, Fabiana S.

AU - Upadhya, Rajendra

AU - Zhao, Dazhi

AU - Schwartz, Gary J.

AU - Teixeira, Mauro M.

AU - Albanese, Chris

AU - Lisanti, Michael P.

AU - Chua, Streamson C.

AU - Weiss, Louis M.

AU - Scherer, Philipp E.

AU - Tanowitz, Herbert B.

N1 - Funding Information: Financial support. This work was supported in part by the National Institutes of Health (AI-076248, HL-73732, AI-06538 to H. B. T., DK55758, CA112023, and RC1 DK086629 to P. E. S., P60-DK020541 to S. C. C. and G. J. S., 1 R03-TW006857 FIRCA to M. M. T. and H. B. T.); Conselho Nacional de Desenvolvimento Científico e Tecnológico (to F. S. M. and M. M. T.); and Fundaxcão de Amparo à Pesquisa do Estado de Minas Gerais (to F. S. M.). This work was also supported by a pilot grant from the Diabetes Research and Training Center, Albert Einstein College of Medicine. Potential conflicts of interest. All authors: No reported conflicts.

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor γ were increased in WAT, whereas protein and mRNA levels of adiponectin were significantly reduced in BAT and WAT. The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection.

AB - Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor γ were increased in WAT, whereas protein and mRNA levels of adiponectin were significantly reduced in BAT and WAT. The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection.

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U2 - 10.1093/infdis/jir840

DO - 10.1093/infdis/jir840

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AN - SCOPUS:84055202591

SN - 0022-1899

VL - 205

SP - 830

EP - 840

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain)

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