Response of an adult patient with pineoblastoma to vorinostat and retinoic acid

Rebecca DeBoer; Hunt Batjer; Maryanne Marymont; Stewart Goldman; Matthew Walker; Numa Gottardi-Littell; Jeffrey Raizer

doi:10.1007/s11060-009-9921-5

Response of an adult patient with pineoblastoma to vorinostat and retinoic acid

Rebecca DeBoer, Hunt Batjer, Maryanne Marymont, Stewart Goldman, Matthew Walker, Numa Gottardi-Littell, Jeffrey Raizer

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid. This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy. Vorinostat and retinoic acid were chosen as an alternative to cytotoxic chemotherapy, which our patient was unable to tolerate, based on preclinical data suggesting efficacy of this combination. MRI demonstrated a complete response to this regimen, which continues to remain stable without evidence of recurrence.

Original language	English (US)
Pages (from-to)	289-292
Number of pages	4
Journal	Journal of Neuro-Oncology
Volume	95
Issue number	2
DOIs	https://doi.org/10.1007/s11060-009-9921-5
State	Published - Jun 11 2009

Keywords

Pineoblastoma
Retinoic acid
Vorinostat

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/s11060-009-9921-5

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abstract = "We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid. This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy. Vorinostat and retinoic acid were chosen as an alternative to cytotoxic chemotherapy, which our patient was unable to tolerate, based on preclinical data suggesting efficacy of this combination. MRI demonstrated a complete response to this regimen, which continues to remain stable without evidence of recurrence.",

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AU - Marymont, Maryanne

AU - Goldman, Stewart

AU - Walker, Matthew

AU - Gottardi-Littell, Numa

AU - Raizer, Jeffrey

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AB - We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid. This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy. Vorinostat and retinoic acid were chosen as an alternative to cytotoxic chemotherapy, which our patient was unable to tolerate, based on preclinical data suggesting efficacy of this combination. MRI demonstrated a complete response to this regimen, which continues to remain stable without evidence of recurrence.

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KW - Retinoic acid

KW - Vorinostat

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Response of an adult patient with pineoblastoma to vorinostat and retinoic acid

Abstract

Keywords

ASJC Scopus subject areas

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