Response of an adult patient with pineoblastoma to vorinostat and retinoic acid

Rebecca DeBoer, Hunt Batjer, Maryanne Marymont, Stewart Goldman, Matthew Walker, Numa Gottardi-Littell, Jeffrey Raizer

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid. This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy. Vorinostat and retinoic acid were chosen as an alternative to cytotoxic chemotherapy, which our patient was unable to tolerate, based on preclinical data suggesting efficacy of this combination. MRI demonstrated a complete response to this regimen, which continues to remain stable without evidence of recurrence.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalJournal of Neuro-Oncology
Volume95
Issue number2
DOIs
StatePublished - Jun 11 2009

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Keywords

  • Pineoblastoma
  • Retinoic acid
  • Vorinostat

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

DeBoer, R., Batjer, H., Marymont, M., Goldman, S., Walker, M., Gottardi-Littell, N., & Raizer, J. (2009). Response of an adult patient with pineoblastoma to vorinostat and retinoic acid. Journal of Neuro-Oncology, 95(2), 289-292. https://doi.org/10.1007/s11060-009-9921-5