Response of the Thymus and Immunologically Induced Lymphopenia

A. M. Denman, E. P. Frenkel, M. Ziff

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.

Original languageEnglish (US)
Pages (from-to)1127-1130
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume125
Issue number4
DOIs
StatePublished - Sep 8 1967

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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