Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Sep 8 1967|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)