Response to a single dose of sildenafil in single-ventricle patients: An echocardiographic evaluation

Kimberly W. Jackson; Ryan J. Butts; Amy J. Svenson; Tim C. McQuinn; Andrew M. Atz

doi:10.1007/s00246-012-0415-4

Response to a single dose of sildenafil in single-ventricle patients: An echocardiographic evaluation

Kimberly W. Jackson, Ryan J. Butts, Amy J. Svenson, Tim C. McQuinn, Andrew M. Atz

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.

Original language	English (US)
Pages (from-to)	1739-1742
Number of pages	4
Journal	Pediatric Cardiology
Volume	34
Issue number	7
DOIs	https://doi.org/10.1007/s00246-012-0415-4
State	Published - Oct 2013

Keywords

Congenital heart disease
Fontan
Pediatric
Univentricular heart

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1007/s00246-012-0415-4

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title = "Response to a single dose of sildenafil in single-ventricle patients: An echocardiographic evaluation",

abstract = "New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.",

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T1 - Response to a single dose of sildenafil in single-ventricle patients

T2 - An echocardiographic evaluation

AU - Jackson, Kimberly W.

AU - Butts, Ryan J.

AU - Svenson, Amy J.

AU - McQuinn, Tim C.

AU - Atz, Andrew M.

PY - 2013/10

Y1 - 2013/10

N2 - New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.

AB - New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.

KW - Congenital heart disease

KW - Fontan

KW - Pediatric

KW - Univentricular heart

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Response to a single dose of sildenafil in single-ventricle patients: An echocardiographic evaluation

Abstract

Keywords

ASJC Scopus subject areas

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