Response to a single dose of sildenafil in single-ventricle patients: An echocardiographic evaluation

Kimberly W. Jackson, Ryan J. Butts, Amy J. Svenson, Tim C. McQuinn, Andrew M. Atz

Research output: Contribution to journalArticle

4 Scopus citations


New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.

Original languageEnglish (US)
Pages (from-to)1739-1742
Number of pages4
JournalPediatric Cardiology
Issue number7
StatePublished - Oct 1 2013



  • Congenital heart disease
  • Fontan
  • Pediatric
  • Univentricular heart

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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