Response to pegylated interferon in a COVID-19–positive elderly woman with primary myelofibrosis treated with ruxolitinib

Arthur E. Frankel; Renuka Reddy; Kayla R. DeSuza; Khaled Deeb; Aaron F. Carlin; Davey Smith; Yushuang Xie; Eknath Naik; Richard T. Silver; Hans C. Hasselbalch

doi:10.1002/ccr3.3997

Response to pegylated interferon in a COVID-19–positive elderly woman with primary myelofibrosis treated with ruxolitinib

Arthur E. Frankel, Renuka Reddy, Kayla R. DeSuza, Khaled Deeb, Aaron F. Carlin, Davey Smith, Yushuang Xie, Eknath Naik, Richard T. Silver, Hans C. Hasselbalch

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An 83-year-old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.

Original language	English (US)
Pages (from-to)	2228-2235
Number of pages	8
Journal	Clinical Case Reports
Volume	9
Issue number	4
DOIs	https://doi.org/10.1002/ccr3.3997
State	Published - Apr 2021
Externally published	Yes

Keywords

COVID-19
interferon
ruxolitinib

ASJC Scopus subject areas

General Medicine

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10.1002/ccr3.3997

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title = "Response to pegylated interferon in a COVID-19–positive elderly woman with primary myelofibrosis treated with ruxolitinib",

abstract = "An 83-year-old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.",

keywords = "COVID-19, interferon, ruxolitinib",

author = "Frankel, {Arthur E.} and Renuka Reddy and DeSuza, {Kayla R.} and Khaled Deeb and Carlin, {Aaron F.} and Davey Smith and Yushuang Xie and Eknath Naik and Silver, {Richard T.} and Hasselbalch, {Hans C.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.",

year = "2021",

month = apr,

doi = "10.1002/ccr3.3997",

language = "English (US)",

volume = "9",

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journal = "Clinical Case Reports",

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T1 - Response to pegylated interferon in a COVID-19–positive elderly woman with primary myelofibrosis treated with ruxolitinib

AU - Frankel, Arthur E.

AU - Reddy, Renuka

AU - DeSuza, Kayla R.

AU - Deeb, Khaled

AU - Carlin, Aaron F.

AU - Smith, Davey

AU - Xie, Yushuang

AU - Naik, Eknath

AU - Silver, Richard T.

AU - Hasselbalch, Hans C.

PY - 2021/4

Y1 - 2021/4

N2 - An 83-year-old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.

AB - An 83-year-old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.

KW - COVID-19

KW - interferon

KW - ruxolitinib

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UR - http://www.scopus.com/inward/citedby.url?scp=85102203722&partnerID=8YFLogxK

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VL - 9

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EP - 2235

JO - Clinical Case Reports

JF - Clinical Case Reports

IS - 4

ER -

Response to pegylated interferon in a COVID-19–positive elderly woman with primary myelofibrosis treated with ruxolitinib

Abstract

Keywords

ASJC Scopus subject areas

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