Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy

D. C. Ihde, F. S. Bilek, M. H. Cohen, P. A. Bunn, J. Eddy, J. D. Minna

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chest radiotherapy was given to 23 patients with small carcinoma of the lung after development of progressive intrathoracic tumor on chemotherapeutic regimens. Treatment schedules were variable, with a median dose of 3,200 rad (32 Gy) in 10 fractions. Objective tumor regression within the radiation portal was observed in 12 patients (52%). Only 3/12 responders did not develop clinically detectable local tumor recurrence before death. Actuarial median time to local tumor progression was 2.5 months in responding and 3.5 months in nonresponding patients. Relapse of intrathoracic small carcinoma despite combination chemotherapy was not effectively treated by chest irradiation in the doses utilized. If sustained local palliation is required in this population, higher doses of radiation should be considered.

Original languageEnglish (US)
Pages (from-to)443-446
Number of pages4
JournalRadiology
Volume132
Issue number2
StatePublished - 1979

Fingerprint

Small Cell Lung Carcinoma
Combination Drug Therapy
Radiotherapy
Thorax
Neoplasms
Radiation
Carcinoma
Recurrence
Appointments and Schedules
Lung
Population
Therapeutics

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy. / Ihde, D. C.; Bilek, F. S.; Cohen, M. H.; Bunn, P. A.; Eddy, J.; Minna, J. D.

In: Radiology, Vol. 132, No. 2, 1979, p. 443-446.

Research output: Contribution to journalArticle

Ihde, D. C. ; Bilek, F. S. ; Cohen, M. H. ; Bunn, P. A. ; Eddy, J. ; Minna, J. D. / Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy. In: Radiology. 1979 ; Vol. 132, No. 2. pp. 443-446.
@article{afbadbdde2844b84b021beb4d048c397,
title = "Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy",
abstract = "Chest radiotherapy was given to 23 patients with small carcinoma of the lung after development of progressive intrathoracic tumor on chemotherapeutic regimens. Treatment schedules were variable, with a median dose of 3,200 rad (32 Gy) in 10 fractions. Objective tumor regression within the radiation portal was observed in 12 patients (52{\%}). Only 3/12 responders did not develop clinically detectable local tumor recurrence before death. Actuarial median time to local tumor progression was 2.5 months in responding and 3.5 months in nonresponding patients. Relapse of intrathoracic small carcinoma despite combination chemotherapy was not effectively treated by chest irradiation in the doses utilized. If sustained local palliation is required in this population, higher doses of radiation should be considered.",
author = "Ihde, {D. C.} and Bilek, {F. S.} and Cohen, {M. H.} and Bunn, {P. A.} and J. Eddy and Minna, {J. D.}",
year = "1979",
language = "English (US)",
volume = "132",
pages = "443--446",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy

AU - Ihde, D. C.

AU - Bilek, F. S.

AU - Cohen, M. H.

AU - Bunn, P. A.

AU - Eddy, J.

AU - Minna, J. D.

PY - 1979

Y1 - 1979

N2 - Chest radiotherapy was given to 23 patients with small carcinoma of the lung after development of progressive intrathoracic tumor on chemotherapeutic regimens. Treatment schedules were variable, with a median dose of 3,200 rad (32 Gy) in 10 fractions. Objective tumor regression within the radiation portal was observed in 12 patients (52%). Only 3/12 responders did not develop clinically detectable local tumor recurrence before death. Actuarial median time to local tumor progression was 2.5 months in responding and 3.5 months in nonresponding patients. Relapse of intrathoracic small carcinoma despite combination chemotherapy was not effectively treated by chest irradiation in the doses utilized. If sustained local palliation is required in this population, higher doses of radiation should be considered.

AB - Chest radiotherapy was given to 23 patients with small carcinoma of the lung after development of progressive intrathoracic tumor on chemotherapeutic regimens. Treatment schedules were variable, with a median dose of 3,200 rad (32 Gy) in 10 fractions. Objective tumor regression within the radiation portal was observed in 12 patients (52%). Only 3/12 responders did not develop clinically detectable local tumor recurrence before death. Actuarial median time to local tumor progression was 2.5 months in responding and 3.5 months in nonresponding patients. Relapse of intrathoracic small carcinoma despite combination chemotherapy was not effectively treated by chest irradiation in the doses utilized. If sustained local palliation is required in this population, higher doses of radiation should be considered.

UR - http://www.scopus.com/inward/record.url?scp=0018392454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018392454&partnerID=8YFLogxK

M3 - Article

VL - 132

SP - 443

EP - 446

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -