Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects

Bryon Adinoff, Michael D. Devous, Douglas B. Cooper, Susan E. Best, Patricia Chandler, Thomas Harris, Carole Anne Cervin, C. Munro Cullum

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Objective: Orbitofrontal cortex regional cerebral blood flow (rCBF) is lower in cocaine-dependent subjects than in non-cocaine-dependent subjects. Performance on the Gambling Task, a test of decision making, is a putative correlate of orbitofrontal cortex activity and is reportedly impaired in drug-dependent subjects. The authors tested the hypothesis that lower Gambling Task scores would be associated with lower resting orbitofrontal cortex rCBF in cocaine-dependent subjects. Method: Fifteen healthy comparison subjects and 13 abstinent cocaine-dependent subjects underwent resting single photon emission computed tomography to measure rCBF, after which they completed the Gambling Task. Results: Resting anterior cingulate and left dorsolateral prefrontal cortex rCBF significantly correlated with performance on the Gambling Task, but orbitofrontal cortex rCBF did not. Left dorsolateral prefrontal cortex rCBF was lower in the cocaine-dependent subjects than in the comparison subjects. Conclusions: Resting anterior cingulate and dorsolateral prefrontal cortex rCBF is significantly related to decision making, as assessed by the Gambling Task.

Original languageEnglish (US)
Pages (from-to)1892-1894
Number of pages3
JournalAmerican Journal of Psychiatry
Volume160
Issue number10
DOIs
StatePublished - Oct 2003

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Cerebrovascular Circulation
Gambling
Regional Blood Flow
Task Performance and Analysis
Prefrontal Cortex
Cocaine
Healthy Volunteers
Gyrus Cinguli
Decision Making
Single-Photon Emission-Computed Tomography

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects. / Adinoff, Bryon; Devous, Michael D.; Cooper, Douglas B.; Best, Susan E.; Chandler, Patricia; Harris, Thomas; Cervin, Carole Anne; Cullum, C. Munro.

In: American Journal of Psychiatry, Vol. 160, No. 10, 10.2003, p. 1892-1894.

Research output: Contribution to journalArticle

Adinoff, Bryon ; Devous, Michael D. ; Cooper, Douglas B. ; Best, Susan E. ; Chandler, Patricia ; Harris, Thomas ; Cervin, Carole Anne ; Cullum, C. Munro. / Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects. In: American Journal of Psychiatry. 2003 ; Vol. 160, No. 10. pp. 1892-1894.
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AU - Harris, Thomas

AU - Cervin, Carole Anne

AU - Cullum, C. Munro

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