TY - JOUR
T1 - Resting state functional MRI reveals abnormal network connectivity in orthostatic tremor
AU - Benito-Leon, Julian
AU - Louis, Elan D.
AU - Manzanedo, Eva
AU - Hernandez-Tamames, Juan Antonio
AU - Alvarez-Linera, Juan
AU - Molina-Arjona, Jose Antonio
AU - Matarazzo, Michele
AU - Romero, Juan Pablo
AU - Dominguez-Gonzalez, Cristina
AU - Domingo-Santos, Angela
AU - Sanchez-Ferro, Alvaro
N1 - Publisher Copyright:
© 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/7/26
Y1 - 2016/7/26
N2 - Very little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patientsmight have deficits in specific aspects of neuropsychological function, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests a possible involvement of frontocerebellar circuits. We examined whether resting-state functional magnetic resonance imaging (fMRI) might provide further insights into the pathogenesis on OT. Resting-state fMRI data in 13 OT patients (11 women and 2 men) and 13 matched healthy controls were analyzed using independent component analysis, in combination with a "dual-regression" technique, to identify group differences in several resting-state networks (RSNs). All participants also underwent neuropsychological testing during the same session. Relative to healthy controls, OT patients showed increased connectivity in RSNs involved in cognitive processes (default mode network [DMN] and frontoparietal networks), and decreased connectivity in the cerebellumand sensorimotor networks.Changes in network integrity were associated not onlywith duration (DMN and medial visual network), but also with cognitive function. Moreover, in at least 2 networks (DMN and medial visual network), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, visual memory, and language). In this exploratory study, we observed selective impairments ofRSNs inOT patients. This and other future resting-state fMRI studiesmight provide a novelmethod to understand the pathophysiological mechanisms of motor and nonmotor features of OT.
AB - Very little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patientsmight have deficits in specific aspects of neuropsychological function, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests a possible involvement of frontocerebellar circuits. We examined whether resting-state functional magnetic resonance imaging (fMRI) might provide further insights into the pathogenesis on OT. Resting-state fMRI data in 13 OT patients (11 women and 2 men) and 13 matched healthy controls were analyzed using independent component analysis, in combination with a "dual-regression" technique, to identify group differences in several resting-state networks (RSNs). All participants also underwent neuropsychological testing during the same session. Relative to healthy controls, OT patients showed increased connectivity in RSNs involved in cognitive processes (default mode network [DMN] and frontoparietal networks), and decreased connectivity in the cerebellumand sensorimotor networks.Changes in network integrity were associated not onlywith duration (DMN and medial visual network), but also with cognitive function. Moreover, in at least 2 networks (DMN and medial visual network), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, visual memory, and language). In this exploratory study, we observed selective impairments ofRSNs inOT patients. This and other future resting-state fMRI studiesmight provide a novelmethod to understand the pathophysiological mechanisms of motor and nonmotor features of OT.
KW - Case-control study
KW - Functional connectivity
KW - Magnetic resonance imaging
KW - Orthostatic tremor
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U2 - 10.1097/MD.0000000000004310
DO - 10.1097/MD.0000000000004310
M3 - Article
C2 - 27442678
AN - SCOPUS:84980002360
SN - 0025-7974
VL - 95
JO - Medicine (United States)
JF - Medicine (United States)
IS - 29
M1 - e4310
ER -