Restoration of the cellular senescence program and repression of telomerase by human chromosome 3

Hiroshi Ohmura, Hidetoshi Tahara, Mikio Suzuki, Toshinori Ide, Motoyuki Shimizu, Mitsuaki A. Yoshida, Eiichi Tahara, Jerry W. Shay, J. Carl Barrett, Mitsuo Oshimura

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.

Original languageEnglish (US)
Pages (from-to)899-904
Number of pages6
JournalJapanese Journal of Cancer Research
Volume86
Issue number10
DOIs
StatePublished - Oct 1995

Fingerprint

Chromosomes, Human, Pair 3
Cell Aging
Telomerase
Human Chromosomes
Renal Cell Carcinoma
Telomere
Telomere Shortening
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Gene Deletion
Cell Division
Chromosomes
Cell Line
Growth
Neoplasms

Keywords

  • Cellular senescence
  • Chromosome 3
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ohmura, H., Tahara, H., Suzuki, M., Ide, T., Shimizu, M., Yoshida, M. A., ... Oshimura, M. (1995). Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Japanese Journal of Cancer Research, 86(10), 899-904. https://doi.org/10.1016/0910-5050(95)96782-Z

Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. / Ohmura, Hiroshi; Tahara, Hidetoshi; Suzuki, Mikio; Ide, Toshinori; Shimizu, Motoyuki; Yoshida, Mitsuaki A.; Tahara, Eiichi; Shay, Jerry W.; Barrett, J. Carl; Oshimura, Mitsuo.

In: Japanese Journal of Cancer Research, Vol. 86, No. 10, 10.1995, p. 899-904.

Research output: Contribution to journalArticle

Ohmura, H, Tahara, H, Suzuki, M, Ide, T, Shimizu, M, Yoshida, MA, Tahara, E, Shay, JW, Barrett, JC & Oshimura, M 1995, 'Restoration of the cellular senescence program and repression of telomerase by human chromosome 3', Japanese Journal of Cancer Research, vol. 86, no. 10, pp. 899-904. https://doi.org/10.1016/0910-5050(95)96782-Z
Ohmura, Hiroshi ; Tahara, Hidetoshi ; Suzuki, Mikio ; Ide, Toshinori ; Shimizu, Motoyuki ; Yoshida, Mitsuaki A. ; Tahara, Eiichi ; Shay, Jerry W. ; Barrett, J. Carl ; Oshimura, Mitsuo. / Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. In: Japanese Journal of Cancer Research. 1995 ; Vol. 86, No. 10. pp. 899-904.
@article{6b1dc692b5734323bc53269740f262d4,
title = "Restoration of the cellular senescence program and repression of telomerase by human chromosome 3",
abstract = "Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.",
keywords = "Cellular senescence, Chromosome 3, Telomerase, Telomere",
author = "Hiroshi Ohmura and Hidetoshi Tahara and Mikio Suzuki and Toshinori Ide and Motoyuki Shimizu and Yoshida, {Mitsuaki A.} and Eiichi Tahara and Shay, {Jerry W.} and Barrett, {J. Carl} and Mitsuo Oshimura",
year = "1995",
month = "10",
doi = "10.1016/0910-5050(95)96782-Z",
language = "English (US)",
volume = "86",
pages = "899--904",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Restoration of the cellular senescence program and repression of telomerase by human chromosome 3

AU - Ohmura, Hiroshi

AU - Tahara, Hidetoshi

AU - Suzuki, Mikio

AU - Ide, Toshinori

AU - Shimizu, Motoyuki

AU - Yoshida, Mitsuaki A.

AU - Tahara, Eiichi

AU - Shay, Jerry W.

AU - Barrett, J. Carl

AU - Oshimura, Mitsuo

PY - 1995/10

Y1 - 1995/10

N2 - Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.

AB - Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.

KW - Cellular senescence

KW - Chromosome 3

KW - Telomerase

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=0028883950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028883950&partnerID=8YFLogxK

U2 - 10.1016/0910-5050(95)96782-Z

DO - 10.1016/0910-5050(95)96782-Z

M3 - Article

C2 - 7493906

AN - SCOPUS:0028883950

VL - 86

SP - 899

EP - 904

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 10

ER -