Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective

Elena Popugaeva, Olga L. Vlasova, Ilya Bezprozvanny

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that primarily compromises memory formation and storage. Several hypotheses regarding the pathogenesis of AD have been proposed; however, no cure is available to date. Here we describe the calcium hypothesis of AD, which is gaining popularity. We present data supporting this hypothesis and focus on a recently discovered calcium-signaling pathway that is dysregulated in AD and propose targets for the development of disease-modifying therapies.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalNeurodegenerative disease management
Volume5
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • Alzheimer disease
  • Ca2+ signaling
  • mushroom spine
  • neuronal store-operated Ca2+ channels
  • synapse

ASJC Scopus subject areas

  • Medicine(all)

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