Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that primarily compromises memory formation and storage. Several hypotheses regarding the pathogenesis of AD have been proposed; however, no cure is available to date. Here we describe the calcium hypothesis of AD, which is gaining popularity. We present data supporting this hypothesis and focus on a recently discovered calcium-signaling pathway that is dysregulated in AD and propose targets for the development of disease-modifying therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 395-398 |
| Number of pages | 4 |
| Journal | Neurodegenerative disease management |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 2015 |
Keywords
- Alzheimer disease
- Ca2+ signaling
- mushroom spine
- neuronal store-operated Ca2+ channels
- synapse
ASJC Scopus subject areas
- General Medicine