Abstract
Stressful life events have been associated with the onset and/or exacerbation of multiple sclerosis (MS). Our previous studies have indicated that restraint stress (RS) reduces inflammation and virus-induced chemokine expression in the Theiler's virus-induced demyelination (TVID) model of MS. Here we report that RS significantly reduced the virus-induced interferon-γ mRNA levels in the brain. Additionally, mRNA levels of lymphotoxin-β, tumor necrosis factor-α, and interferon-γ in the brain were negatively correlated with viral titers in the brain. These results indicated an immunosuppressive effect of stress during early TVID causing impaired viral clearance, which may be a potential exacerbating factor for later demyelination.
Original language | English (US) |
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Pages (from-to) | 49-61 |
Number of pages | 13 |
Journal | Journal of Neuroimmunology |
Volume | 178 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2006 |
Keywords
- Cytokines
- Restraint stress
- Theiler's virus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology