Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

George Ostapowicz, Robert J. Fontana, Frank V. Schioødt, Anne Larson, Timothy J. Davern, Steven H B Han, Timothy M. McCashland, A. Obaid Shakil, J. Eileen Hay, Linda Hynan, Jeffrey S. Crippin, Andres T. Blei, Grace Samuel, Joan Reisch, William M. Lee, Raj Santyanarayana, Cary Caldwell, Lawton Shick, Nathan Bass, Smita Rouillard & 13 others Evren Atillasoy, Steven Flamm, Kent G. Benner, Hugo R. Rosen, Paul Martin, Risë Stribling, Eugene R. Schiff, Maria B. Torres, Victor Navarro, Brendan McGuire, Raymond Chung, Diane Abraczinskas, Jules Dienstag

Research output: Contribution to journalArticle

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Abstract

Background: Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition. Objective: To describe the clinical features, presumed causes, and short-term outcomes of acute liver failure. Design: Prospective cohort study. Setting: 17 tertiary care centers participating in the U.S. Acute Liver Failure Study Group. Patients: 308 consecutive patients with acute liver failure, admitted over a 41-month period. Measurements: Detailed clinical and laboratory data collected during hospitalization, including outcome 3 weeks after study admission. Results: 73% of patients were women; median age was 38 years. Acetaminophen overdose was the most common apparent cause of acute liver failure, accounting for 39% of cases. Idiosyncratic drug reactions were the presumptive cause in 13% of cases viral hepatitis A and B combined were implicated in 12% of cases, and 17% of cases were of indeterminate cause. Overall patient survival at 3 weeks was 67%. Twenty-nine percent of patients had liver transplantation, and 43% survived without transplantation. Short-term transplant-free survival varied greatly, from 68% for patients with acetaminophen-related liver failure to 25% and 17% for those with other drug reactions and liver failure of indeterminate cause, respectively. Coma grade at admission appeared to be associated with outcome, but age and symptom duration did not. Conclusions: Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure. Apparent cause and coma grade at admission were associated with outcome. Although transplantation may improve patient survival, it was unavailable or unnecessary for most patients.

Original languageEnglish (US)
Pages (from-to)947-954
Number of pages8
JournalAnnals of Internal Medicine
Volume137
Issue number12
StatePublished - Dec 17 2002

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Acute Liver Failure
Tertiary Care Centers
Prospective Studies
Acetaminophen
Liver Failure
Coma
Hepatitis
Survival
Transplantation
Drug Overdose
Hepatitis A
Hepatitis B
Pharmaceutical Preparations
Liver Transplantation
Hospitalization
Cohort Studies
Transplants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ostapowicz, G., Fontana, R. J., Schioødt, F. V., Larson, A., Davern, T. J., Han, S. H. B., ... Dienstag, J. (2002). Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Annals of Internal Medicine, 137(12), 947-954.

Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. / Ostapowicz, George; Fontana, Robert J.; Schioødt, Frank V.; Larson, Anne; Davern, Timothy J.; Han, Steven H B; McCashland, Timothy M.; Shakil, A. Obaid; Hay, J. Eileen; Hynan, Linda; Crippin, Jeffrey S.; Blei, Andres T.; Samuel, Grace; Reisch, Joan; Lee, William M.; Santyanarayana, Raj; Caldwell, Cary; Shick, Lawton; Bass, Nathan; Rouillard, Smita; Atillasoy, Evren; Flamm, Steven; Benner, Kent G.; Rosen, Hugo R.; Martin, Paul; Stribling, Risë; Schiff, Eugene R.; Torres, Maria B.; Navarro, Victor; McGuire, Brendan; Chung, Raymond; Abraczinskas, Diane; Dienstag, Jules.

In: Annals of Internal Medicine, Vol. 137, No. 12, 17.12.2002, p. 947-954.

Research output: Contribution to journalArticle

Ostapowicz, G, Fontana, RJ, Schioødt, FV, Larson, A, Davern, TJ, Han, SHB, McCashland, TM, Shakil, AO, Hay, JE, Hynan, L, Crippin, JS, Blei, AT, Samuel, G, Reisch, J, Lee, WM, Santyanarayana, R, Caldwell, C, Shick, L, Bass, N, Rouillard, S, Atillasoy, E, Flamm, S, Benner, KG, Rosen, HR, Martin, P, Stribling, R, Schiff, ER, Torres, MB, Navarro, V, McGuire, B, Chung, R, Abraczinskas, D & Dienstag, J 2002, 'Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States', Annals of Internal Medicine, vol. 137, no. 12, pp. 947-954.
Ostapowicz G, Fontana RJ, Schioødt FV, Larson A, Davern TJ, Han SHB et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Annals of Internal Medicine. 2002 Dec 17;137(12):947-954.
Ostapowicz, George ; Fontana, Robert J. ; Schioødt, Frank V. ; Larson, Anne ; Davern, Timothy J. ; Han, Steven H B ; McCashland, Timothy M. ; Shakil, A. Obaid ; Hay, J. Eileen ; Hynan, Linda ; Crippin, Jeffrey S. ; Blei, Andres T. ; Samuel, Grace ; Reisch, Joan ; Lee, William M. ; Santyanarayana, Raj ; Caldwell, Cary ; Shick, Lawton ; Bass, Nathan ; Rouillard, Smita ; Atillasoy, Evren ; Flamm, Steven ; Benner, Kent G. ; Rosen, Hugo R. ; Martin, Paul ; Stribling, Risë ; Schiff, Eugene R. ; Torres, Maria B. ; Navarro, Victor ; McGuire, Brendan ; Chung, Raymond ; Abraczinskas, Diane ; Dienstag, Jules. / Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. In: Annals of Internal Medicine. 2002 ; Vol. 137, No. 12. pp. 947-954.
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title = "Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States",
abstract = "Background: Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition. Objective: To describe the clinical features, presumed causes, and short-term outcomes of acute liver failure. Design: Prospective cohort study. Setting: 17 tertiary care centers participating in the U.S. Acute Liver Failure Study Group. Patients: 308 consecutive patients with acute liver failure, admitted over a 41-month period. Measurements: Detailed clinical and laboratory data collected during hospitalization, including outcome 3 weeks after study admission. Results: 73{\%} of patients were women; median age was 38 years. Acetaminophen overdose was the most common apparent cause of acute liver failure, accounting for 39{\%} of cases. Idiosyncratic drug reactions were the presumptive cause in 13{\%} of cases viral hepatitis A and B combined were implicated in 12{\%} of cases, and 17{\%} of cases were of indeterminate cause. Overall patient survival at 3 weeks was 67{\%}. Twenty-nine percent of patients had liver transplantation, and 43{\%} survived without transplantation. Short-term transplant-free survival varied greatly, from 68{\%} for patients with acetaminophen-related liver failure to 25{\%} and 17{\%} for those with other drug reactions and liver failure of indeterminate cause, respectively. Coma grade at admission appeared to be associated with outcome, but age and symptom duration did not. Conclusions: Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure. Apparent cause and coma grade at admission were associated with outcome. Although transplantation may improve patient survival, it was unavailable or unnecessary for most patients.",
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T1 - Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

AU - Ostapowicz, George

AU - Fontana, Robert J.

AU - Schioødt, Frank V.

AU - Larson, Anne

AU - Davern, Timothy J.

AU - Han, Steven H B

AU - McCashland, Timothy M.

AU - Shakil, A. Obaid

AU - Hay, J. Eileen

AU - Hynan, Linda

AU - Crippin, Jeffrey S.

AU - Blei, Andres T.

AU - Samuel, Grace

AU - Reisch, Joan

AU - Lee, William M.

AU - Santyanarayana, Raj

AU - Caldwell, Cary

AU - Shick, Lawton

AU - Bass, Nathan

AU - Rouillard, Smita

AU - Atillasoy, Evren

AU - Flamm, Steven

AU - Benner, Kent G.

AU - Rosen, Hugo R.

AU - Martin, Paul

AU - Stribling, Risë

AU - Schiff, Eugene R.

AU - Torres, Maria B.

AU - Navarro, Victor

AU - McGuire, Brendan

AU - Chung, Raymond

AU - Abraczinskas, Diane

AU - Dienstag, Jules

PY - 2002/12/17

Y1 - 2002/12/17

N2 - Background: Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition. Objective: To describe the clinical features, presumed causes, and short-term outcomes of acute liver failure. Design: Prospective cohort study. Setting: 17 tertiary care centers participating in the U.S. Acute Liver Failure Study Group. Patients: 308 consecutive patients with acute liver failure, admitted over a 41-month period. Measurements: Detailed clinical and laboratory data collected during hospitalization, including outcome 3 weeks after study admission. Results: 73% of patients were women; median age was 38 years. Acetaminophen overdose was the most common apparent cause of acute liver failure, accounting for 39% of cases. Idiosyncratic drug reactions were the presumptive cause in 13% of cases viral hepatitis A and B combined were implicated in 12% of cases, and 17% of cases were of indeterminate cause. Overall patient survival at 3 weeks was 67%. Twenty-nine percent of patients had liver transplantation, and 43% survived without transplantation. Short-term transplant-free survival varied greatly, from 68% for patients with acetaminophen-related liver failure to 25% and 17% for those with other drug reactions and liver failure of indeterminate cause, respectively. Coma grade at admission appeared to be associated with outcome, but age and symptom duration did not. Conclusions: Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure. Apparent cause and coma grade at admission were associated with outcome. Although transplantation may improve patient survival, it was unavailable or unnecessary for most patients.

AB - Background: Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition. Objective: To describe the clinical features, presumed causes, and short-term outcomes of acute liver failure. Design: Prospective cohort study. Setting: 17 tertiary care centers participating in the U.S. Acute Liver Failure Study Group. Patients: 308 consecutive patients with acute liver failure, admitted over a 41-month period. Measurements: Detailed clinical and laboratory data collected during hospitalization, including outcome 3 weeks after study admission. Results: 73% of patients were women; median age was 38 years. Acetaminophen overdose was the most common apparent cause of acute liver failure, accounting for 39% of cases. Idiosyncratic drug reactions were the presumptive cause in 13% of cases viral hepatitis A and B combined were implicated in 12% of cases, and 17% of cases were of indeterminate cause. Overall patient survival at 3 weeks was 67%. Twenty-nine percent of patients had liver transplantation, and 43% survived without transplantation. Short-term transplant-free survival varied greatly, from 68% for patients with acetaminophen-related liver failure to 25% and 17% for those with other drug reactions and liver failure of indeterminate cause, respectively. Coma grade at admission appeared to be associated with outcome, but age and symptom duration did not. Conclusions: Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure. Apparent cause and coma grade at admission were associated with outcome. Although transplantation may improve patient survival, it was unavailable or unnecessary for most patients.

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