Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery

George O. Waring, Michael J. Lynn, Henry Gelender, Peter R. Laibson, Richard L. Lindstrom, William D. Myers, Stephen A. Obstbaum, J. James Rowsey, Marguerite B. McDonald, David J. Schanzlin, Robert D. Sperduto, Linda B. Bourque, George O. Waring, Ceretha S. Cartwright, Eugene B. Steinberg, Harrison D Cavanagh, William H. Coles, Louis A. Wilson, E. C. Hall, Steven D. Moffitt & 67 others Portia Griffin, Vicki Rice, Sidney Mandelbaum, Richard K. Forster, William Culbertson, Mary Anne Edwards, Teresa Obeso, Marguerite McDonald, Aran Safir, Herbert E. Kaufman, Rise Ochsner, Joseph A. Baldone, John Lindberg, Rudy Franklin, Deborah Poloson, Mike Ostrick, Donald J. Doughman, J. Daniel Nelson, J. Douglas Cameron, Pat Williams, Penny Asbell, Steven M. Podos, Michael J. Newton, George Pardos, Norma Justin, Hal D. Balyeat, James C. Hays, Wayne F. March, Jack Whiteside, Becky Hewett, Douglas Corley, Beth Kuns, Ronald E. Smith, James J. Salz, Douglas L. Steel, Richard A. Villasenor, Jenny Garbus, Jan Reinig, Robert C. Arends, John W. Cowden, William T. Sallee, Robert L. Stephenson, Paul Fecko, Henry J. Spiro, Vicki Roszka-Duggan, Juan J. Arentsen, Michael A. Naidoff, Elisabeth Cohen, Nubia Cantillo, Roy Monlux, Michael Isaac, Beverly Cosand, Shari Swift, Darrl Clark, Vicki Shadix, Jay H. Krachmer, Robert J. Hardy, James P McCulley, Walter J. Stark, Richard A. Thoft, James V. Aquavella, Jules L. Baum, Joel Sugar, James Ware, Michale J. Lynn, Ronald G. Geller, Ralph J. Helmsen

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.

Original languageEnglish (US)
Pages (from-to)307-198
Number of pages110
JournalOphthalmology
Volume92
Issue number2
DOIs
StatePublished - 1985

Fingerprint

Radial Keratotomy
Glare
Myopia
Visual Acuity
Emmetropia
Diamond
Astigmatism
Controlled Clinical Trials
Ultrasonics

Keywords

  • astigmatism
  • clinical trial
  • cornea
  • glare
  • myopia
  • radial keratotomy
  • refractive keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Waring, G. O., Lynn, M. J., Gelender, H., Laibson, P. R., Lindstrom, R. L., Myers, W. D., ... Helmsen, R. J. (1985). Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery. Ophthalmology, 92(2), 307-198. https://doi.org/10.1016/S0161-6420(85)34054-X

Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery. / Waring, George O.; Lynn, Michael J.; Gelender, Henry; Laibson, Peter R.; Lindstrom, Richard L.; Myers, William D.; Obstbaum, Stephen A.; Rowsey, J. James; McDonald, Marguerite B.; Schanzlin, David J.; Sperduto, Robert D.; Bourque, Linda B.; Waring, George O.; Cartwright, Ceretha S.; Steinberg, Eugene B.; Cavanagh, Harrison D; Coles, William H.; Wilson, Louis A.; Hall, E. C.; Moffitt, Steven D.; Griffin, Portia; Rice, Vicki; Mandelbaum, Sidney; Forster, Richard K.; Culbertson, William; Edwards, Mary Anne; Obeso, Teresa; McDonald, Marguerite; Safir, Aran; Kaufman, Herbert E.; Ochsner, Rise; Baldone, Joseph A.; Lindberg, John; Franklin, Rudy; Poloson, Deborah; Ostrick, Mike; Doughman, Donald J.; Nelson, J. Daniel; Cameron, J. Douglas; Williams, Pat; Asbell, Penny; Podos, Steven M.; Newton, Michael J.; Pardos, George; Justin, Norma; Balyeat, Hal D.; Hays, James C.; March, Wayne F.; Whiteside, Jack; Hewett, Becky; Corley, Douglas; Kuns, Beth; Smith, Ronald E.; Salz, James J.; Steel, Douglas L.; Villasenor, Richard A.; Garbus, Jenny; Reinig, Jan; Arends, Robert C.; Cowden, John W.; Sallee, William T.; L. Stephenson, Robert; Fecko, Paul; Spiro, Henry J.; Roszka-Duggan, Vicki; Arentsen, Juan J.; Naidoff, Michael A.; Cohen, Elisabeth; Cantillo, Nubia; Monlux, Roy; Isaac, Michael; Cosand, Beverly; Swift, Shari; Clark, Darrl; Shadix, Vicki; Krachmer, Jay H.; Hardy, Robert J.; McCulley, James P; Stark, Walter J.; Thoft, Richard A.; Aquavella, James V.; Baum, Jules L.; Sugar, Joel; Ware, James; Lynn, Michale J.; Geller, Ronald G.; Helmsen, Ralph J.

In: Ophthalmology, Vol. 92, No. 2, 1985, p. 307-198.

Research output: Contribution to journalArticle

Waring, GO, Lynn, MJ, Gelender, H, Laibson, PR, Lindstrom, RL, Myers, WD, Obstbaum, SA, Rowsey, JJ, McDonald, MB, Schanzlin, DJ, Sperduto, RD, Bourque, LB, Waring, GO, Cartwright, CS, Steinberg, EB, Cavanagh, HD, Coles, WH, Wilson, LA, Hall, EC, Moffitt, SD, Griffin, P, Rice, V, Mandelbaum, S, Forster, RK, Culbertson, W, Edwards, MA, Obeso, T, McDonald, M, Safir, A, Kaufman, HE, Ochsner, R, Baldone, JA, Lindberg, J, Franklin, R, Poloson, D, Ostrick, M, Doughman, DJ, Nelson, JD, Cameron, JD, Williams, P, Asbell, P, Podos, SM, Newton, MJ, Pardos, G, Justin, N, Balyeat, HD, Hays, JC, March, WF, Whiteside, J, Hewett, B, Corley, D, Kuns, B, Smith, RE, Salz, JJ, Steel, DL, Villasenor, RA, Garbus, J, Reinig, J, Arends, RC, Cowden, JW, Sallee, WT, L. Stephenson, R, Fecko, P, Spiro, HJ, Roszka-Duggan, V, Arentsen, JJ, Naidoff, MA, Cohen, E, Cantillo, N, Monlux, R, Isaac, M, Cosand, B, Swift, S, Clark, D, Shadix, V, Krachmer, JH, Hardy, RJ, McCulley, JP, Stark, WJ, Thoft, RA, Aquavella, JV, Baum, JL, Sugar, J, Ware, J, Lynn, MJ, Geller, RG & Helmsen, RJ 1985, 'Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery', Ophthalmology, vol. 92, no. 2, pp. 307-198. https://doi.org/10.1016/S0161-6420(85)34054-X
Waring, George O. ; Lynn, Michael J. ; Gelender, Henry ; Laibson, Peter R. ; Lindstrom, Richard L. ; Myers, William D. ; Obstbaum, Stephen A. ; Rowsey, J. James ; McDonald, Marguerite B. ; Schanzlin, David J. ; Sperduto, Robert D. ; Bourque, Linda B. ; Waring, George O. ; Cartwright, Ceretha S. ; Steinberg, Eugene B. ; Cavanagh, Harrison D ; Coles, William H. ; Wilson, Louis A. ; Hall, E. C. ; Moffitt, Steven D. ; Griffin, Portia ; Rice, Vicki ; Mandelbaum, Sidney ; Forster, Richard K. ; Culbertson, William ; Edwards, Mary Anne ; Obeso, Teresa ; McDonald, Marguerite ; Safir, Aran ; Kaufman, Herbert E. ; Ochsner, Rise ; Baldone, Joseph A. ; Lindberg, John ; Franklin, Rudy ; Poloson, Deborah ; Ostrick, Mike ; Doughman, Donald J. ; Nelson, J. Daniel ; Cameron, J. Douglas ; Williams, Pat ; Asbell, Penny ; Podos, Steven M. ; Newton, Michael J. ; Pardos, George ; Justin, Norma ; Balyeat, Hal D. ; Hays, James C. ; March, Wayne F. ; Whiteside, Jack ; Hewett, Becky ; Corley, Douglas ; Kuns, Beth ; Smith, Ronald E. ; Salz, James J. ; Steel, Douglas L. ; Villasenor, Richard A. ; Garbus, Jenny ; Reinig, Jan ; Arends, Robert C. ; Cowden, John W. ; Sallee, William T. ; L. Stephenson, Robert ; Fecko, Paul ; Spiro, Henry J. ; Roszka-Duggan, Vicki ; Arentsen, Juan J. ; Naidoff, Michael A. ; Cohen, Elisabeth ; Cantillo, Nubia ; Monlux, Roy ; Isaac, Michael ; Cosand, Beverly ; Swift, Shari ; Clark, Darrl ; Shadix, Vicki ; Krachmer, Jay H. ; Hardy, Robert J. ; McCulley, James P ; Stark, Walter J. ; Thoft, Richard A. ; Aquavella, James V. ; Baum, Jules L. ; Sugar, Joel ; Ware, James ; Lynn, Michale J. ; Geller, Ronald G. ; Helmsen, Ralph J. / Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery. In: Ophthalmology. 1985 ; Vol. 92, No. 2. pp. 307-198.
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abstract = "The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60{\%} were within ±1.00 diopter of emmetropia; 30{\%} were undercorrected and 10{\%} were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78{\%} of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19{\%} of eyes.",
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T1 - Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery

AU - Waring, George O.

AU - Lynn, Michael J.

AU - Gelender, Henry

AU - Laibson, Peter R.

AU - Lindstrom, Richard L.

AU - Myers, William D.

AU - Obstbaum, Stephen A.

AU - Rowsey, J. James

AU - McDonald, Marguerite B.

AU - Schanzlin, David J.

AU - Sperduto, Robert D.

AU - Bourque, Linda B.

AU - Waring, George O.

AU - Cartwright, Ceretha S.

AU - Steinberg, Eugene B.

AU - Cavanagh, Harrison D

AU - Coles, William H.

AU - Wilson, Louis A.

AU - Hall, E. C.

AU - Moffitt, Steven D.

AU - Griffin, Portia

AU - Rice, Vicki

AU - Mandelbaum, Sidney

AU - Forster, Richard K.

AU - Culbertson, William

AU - Edwards, Mary Anne

AU - Obeso, Teresa

AU - McDonald, Marguerite

AU - Safir, Aran

AU - Kaufman, Herbert E.

AU - Ochsner, Rise

AU - Baldone, Joseph A.

AU - Lindberg, John

AU - Franklin, Rudy

AU - Poloson, Deborah

AU - Ostrick, Mike

AU - Doughman, Donald J.

AU - Nelson, J. Daniel

AU - Cameron, J. Douglas

AU - Williams, Pat

AU - Asbell, Penny

AU - Podos, Steven M.

AU - Newton, Michael J.

AU - Pardos, George

AU - Justin, Norma

AU - Balyeat, Hal D.

AU - Hays, James C.

AU - March, Wayne F.

AU - Whiteside, Jack

AU - Hewett, Becky

AU - Corley, Douglas

AU - Kuns, Beth

AU - Smith, Ronald E.

AU - Salz, James J.

AU - Steel, Douglas L.

AU - Villasenor, Richard A.

AU - Garbus, Jenny

AU - Reinig, Jan

AU - Arends, Robert C.

AU - Cowden, John W.

AU - Sallee, William T.

AU - L. Stephenson, Robert

AU - Fecko, Paul

AU - Spiro, Henry J.

AU - Roszka-Duggan, Vicki

AU - Arentsen, Juan J.

AU - Naidoff, Michael A.

AU - Cohen, Elisabeth

AU - Cantillo, Nubia

AU - Monlux, Roy

AU - Isaac, Michael

AU - Cosand, Beverly

AU - Swift, Shari

AU - Clark, Darrl

AU - Shadix, Vicki

AU - Krachmer, Jay H.

AU - Hardy, Robert J.

AU - McCulley, James P

AU - Stark, Walter J.

AU - Thoft, Richard A.

AU - Aquavella, James V.

AU - Baum, Jules L.

AU - Sugar, Joel

AU - Ware, James

AU - Lynn, Michale J.

AU - Geller, Ronald G.

AU - Helmsen, Ralph J.

PY - 1985

Y1 - 1985

N2 - The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.

AB - The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.

KW - astigmatism

KW - clinical trial

KW - cornea

KW - glare

KW - myopia

KW - radial keratotomy

KW - refractive keratoplasty

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