Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery

George O. Waring; Michael J. Lynn; Henry Gelender; Peter R. Laibson; Richard L. Lindstrom; William D. Myers; Stephen A. Obstbaum; J. James Rowsey; Marguerite B. McDonald; David J. Schanzlin; Robert D. Sperduto; Linda B. Bourque; George O. Waring; Ceretha S. Cartwright; Eugene B. Steinberg; Harrison D Cavanagh; William H. Coles; Louis A. Wilson; E. C. Hall; Steven D. Moffitt; Portia Griffin; Vicki Rice; Sidney Mandelbaum; Richard K. Forster; William Culbertson; Mary Anne Edwards; Teresa Obeso; Marguerite McDonald; Aran Safir; Herbert E. Kaufman; Rise Ochsner; Joseph A. Baldone; John Lindberg; Rudy Franklin; Deborah Poloson; Mike Ostrick; Donald J. Doughman; J. Daniel Nelson; J. Douglas Cameron; Pat Williams; Penny Asbell; Steven M. Podos; Michael J. Newton; George Pardos; Norma Justin; Hal D. Balyeat; James C. Hays; Wayne F. March; Jack Whiteside; Becky Hewett; Douglas Corley; Beth Kuns; Ronald E. Smith; James J. Salz; Douglas L. Steel; Richard A. Villasenor; Jenny Garbus; Jan Reinig; Robert C. Arends; John W. Cowden; William T. Sallee; Robert L. Stephenson; Paul Fecko; Henry J. Spiro; Vicki Roszka-Duggan; Juan J. Arentsen; Michael A. Naidoff; Elisabeth Cohen; Nubia Cantillo; Roy Monlux; Michael Isaac; Beverly Cosand; Shari Swift; Darrl Clark; Vicki Shadix; Jay H. Krachmer; Robert J. Hardy; James P McCulley; Walter J. Stark; Richard A. Thoft; James V. Aquavella; Jules L. Baum; Joel Sugar; James Ware; Michale J. Lynn; Ronald G. Geller; Ralph J. Helmsen

doi:10.1016/S0161-6420(85)34054-X

Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery

George O. Waring, Michael J. Lynn, Henry Gelender, Peter R. Laibson, Richard L. Lindstrom, William D. Myers, Stephen A. Obstbaum, J. James Rowsey, Marguerite B. McDonald, David J. Schanzlin, Robert D. Sperduto, Linda B. Bourque, George O. Waring, Ceretha S. Cartwright, Eugene B. Steinberg, Harrison D Cavanagh, William H. Coles, Louis A. Wilson, E. C. Hall, Steven D. MoffittPortia Griffin, Vicki Rice, Sidney Mandelbaum, Richard K. Forster, William Culbertson, Mary Anne Edwards, Teresa Obeso, Marguerite McDonald, Aran Safir, Herbert E. Kaufman, Rise Ochsner, Joseph A. Baldone, John Lindberg, Rudy Franklin, Deborah Poloson, Mike Ostrick, Donald J. Doughman, J. Daniel Nelson, J. Douglas Cameron, Pat Williams, Penny Asbell, Steven M. Podos, Michael J. Newton, George Pardos, Norma Justin, Hal D. Balyeat, James C. Hays, Wayne F. March, Jack Whiteside, Becky Hewett, Douglas Corley, Beth Kuns, Ronald E. Smith, James J. Salz, Douglas L. Steel, Richard A. Villasenor, Jenny Garbus, Jan Reinig, Robert C. Arends, John W. Cowden, William T. Sallee, Robert L. Stephenson, Paul Fecko, Henry J. Spiro, Vicki Roszka-Duggan, Juan J. Arentsen, Michael A. Naidoff, Elisabeth Cohen, Nubia Cantillo, Roy Monlux, Michael Isaac, Beverly Cosand, Shari Swift, Darrl Clark, Vicki Shadix, Jay H. Krachmer, Robert J. Hardy, James P McCulley, Walter J. Stark, Richard A. Thoft, James V. Aquavella, Jules L. Baum, Joel Sugar, James Ware, Michale J. Lynn, Ronald G. Geller, Ralph J. Helmsen

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

Abstract

The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.

Original language	English (US)
Pages (from-to)	177-198
Number of pages	22
Journal	Ophthalmology
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/S0161-6420(85)34054-X
State	Published - 1985

Keywords

astigmatism
clinical trial
cornea
glare
myopia
radial keratotomy
refractive keratoplasty

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/S0161-6420(85)34054-X

Cite this

Waring, G. O., Lynn, M. J., Gelender, H., Laibson, P. R., Lindstrom, R. L., Myers, W. D., Obstbaum, S. A., Rowsey, J. J., McDonald, M. B., Schanzlin, D. J., Sperduto, R. D., Bourque, L. B., Waring, G. O., Cartwright, C. S., Steinberg, E. B., Cavanagh, H. D., Coles, W. H., Wilson, L. A., Hall, E. C., ... Helmsen, R. J. (1985). Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery. Ophthalmology, 92(2), 177-198. https://doi.org/10.1016/S0161-6420(85)34054-X

Waring, GO, Lynn, MJ, Gelender, H, Laibson, PR, Lindstrom, RL, Myers, WD, Obstbaum, SA, Rowsey, JJ, McDonald, MB, Schanzlin, DJ, Sperduto, RD, Bourque, LB, Waring, GO, Cartwright, CS, Steinberg, EB, Cavanagh, HD, Coles, WH, Wilson, LA, Hall, EC, Moffitt, SD, Griffin, P, Rice, V, Mandelbaum, S, Forster, RK, Culbertson, W, Edwards, MA, Obeso, T, McDonald, M, Safir, A, Kaufman, HE, Ochsner, R, Baldone, JA, Lindberg, J, Franklin, R, Poloson, D, Ostrick, M, Doughman, DJ, Nelson, JD, Cameron, JD, Williams, P, Asbell, P, Podos, SM, Newton, MJ, Pardos, G, Justin, N, Balyeat, HD, Hays, JC, March, WF, Whiteside, J, Hewett, B, Corley, D, Kuns, B, Smith, RE, Salz, JJ, Steel, DL, Villasenor, RA, Garbus, J, Reinig, J, Arends, RC, Cowden, JW, Sallee, WT, L. Stephenson, R, Fecko, P, Spiro, HJ, Roszka-Duggan, V, Arentsen, JJ, Naidoff, MA, Cohen, E, Cantillo, N, Monlux, R, Isaac, M, Cosand, B, Swift, S, Clark, D, Shadix, V, Krachmer, JH, Hardy, RJ, McCulley, JP, Stark, WJ, Thoft, RA, Aquavella, JV, Baum, JL, Sugar, J, Ware, J, Lynn, MJ, Geller, RG & Helmsen, RJ 1985, 'Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery', Ophthalmology, vol. 92, no. 2, pp. 177-198. https://doi.org/10.1016/S0161-6420(85)34054-X

@article{638129f222c245f8af346061d5f8eec2,

title = "Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery",

abstract = "The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.",

keywords = "astigmatism, clinical trial, cornea, glare, myopia, radial keratotomy, refractive keratoplasty",

author = "Waring, {George O.} and Lynn, {Michael J.} and Henry Gelender and Laibson, {Peter R.} and Lindstrom, {Richard L.} and Myers, {William D.} and Obstbaum, {Stephen A.} and Rowsey, {J. James} and McDonald, {Marguerite B.} and Schanzlin, {David J.} and Sperduto, {Robert D.} and Bourque, {Linda B.} and Waring, {George O.} and Cartwright, {Ceretha S.} and Steinberg, {Eugene B.} and Cavanagh, {Harrison D} and Coles, {William H.} and Wilson, {Louis A.} and Hall, {E. C.} and Moffitt, {Steven D.} and Portia Griffin and Vicki Rice and Sidney Mandelbaum and Forster, {Richard K.} and William Culbertson and Edwards, {Mary Anne} and Teresa Obeso and Marguerite McDonald and Aran Safir and Kaufman, {Herbert E.} and Rise Ochsner and Baldone, {Joseph A.} and John Lindberg and Rudy Franklin and Deborah Poloson and Mike Ostrick and Doughman, {Donald J.} and Nelson, {J. Daniel} and Cameron, {J. Douglas} and Pat Williams and Penny Asbell and Podos, {Steven M.} and Newton, {Michael J.} and George Pardos and Norma Justin and Balyeat, {Hal D.} and Hays, {James C.} and March, {Wayne F.} and Jack Whiteside and Becky Hewett and Douglas Corley and Beth Kuns and Smith, {Ronald E.} and Salz, {James J.} and Steel, {Douglas L.} and Villasenor, {Richard A.} and Jenny Garbus and Jan Reinig and Arends, {Robert C.} and Cowden, {John W.} and Sallee, {William T.} and {L. Stephenson}, Robert and Paul Fecko and Spiro, {Henry J.} and Vicki Roszka-Duggan and Arentsen, {Juan J.} and Naidoff, {Michael A.} and Elisabeth Cohen and Nubia Cantillo and Roy Monlux and Michael Isaac and Beverly Cosand and Shari Swift and Darrl Clark and Vicki Shadix and Krachmer, {Jay H.} and Hardy, {Robert J.} and McCulley, {James P} and Stark, {Walter J.} and Thoft, {Richard A.} and Aquavella, {James V.} and Baum, {Jules L.} and Joel Sugar and James Ware and Lynn, {Michale J.} and Geller, {Ronald G.} and Helmsen, {Ralph J.}",

note = "Funding Information: Funded by the National Eye Institute Grant Nos. EY03761, EY03756, EY03755, EY03764, EY03753, EY03751, EY03767, EY04176, EY03752, and EY03765.",

year = "1985",

doi = "10.1016/S0161-6420(85)34054-X",

language = "English (US)",

volume = "92",

pages = "177--198",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery

AU - Waring, George O.

AU - Lynn, Michael J.

AU - Gelender, Henry

AU - Laibson, Peter R.

AU - Lindstrom, Richard L.

AU - Myers, William D.

AU - Obstbaum, Stephen A.

AU - Rowsey, J. James

AU - McDonald, Marguerite B.

AU - Schanzlin, David J.

AU - Sperduto, Robert D.

AU - Bourque, Linda B.

AU - Waring, George O.

AU - Cartwright, Ceretha S.

AU - Steinberg, Eugene B.

AU - Cavanagh, Harrison D

AU - Coles, William H.

AU - Wilson, Louis A.

AU - Hall, E. C.

AU - Moffitt, Steven D.

AU - Griffin, Portia

AU - Rice, Vicki

AU - Mandelbaum, Sidney

AU - Forster, Richard K.

AU - Culbertson, William

AU - Edwards, Mary Anne

AU - Obeso, Teresa

AU - McDonald, Marguerite

AU - Safir, Aran

AU - Kaufman, Herbert E.

AU - Ochsner, Rise

AU - Baldone, Joseph A.

AU - Lindberg, John

AU - Franklin, Rudy

AU - Poloson, Deborah

AU - Ostrick, Mike

AU - Doughman, Donald J.

AU - Nelson, J. Daniel

AU - Cameron, J. Douglas

AU - Williams, Pat

AU - Asbell, Penny

AU - Podos, Steven M.

AU - Newton, Michael J.

AU - Pardos, George

AU - Justin, Norma

AU - Balyeat, Hal D.

AU - Hays, James C.

AU - March, Wayne F.

AU - Whiteside, Jack

AU - Hewett, Becky

AU - Corley, Douglas

AU - Kuns, Beth

AU - Smith, Ronald E.

AU - Salz, James J.

AU - Steel, Douglas L.

AU - Villasenor, Richard A.

AU - Garbus, Jenny

AU - Reinig, Jan

AU - Arends, Robert C.

AU - Cowden, John W.

AU - Sallee, William T.

AU - L. Stephenson, Robert

AU - Fecko, Paul

AU - Spiro, Henry J.

AU - Roszka-Duggan, Vicki

AU - Arentsen, Juan J.

AU - Naidoff, Michael A.

AU - Cohen, Elisabeth

AU - Cantillo, Nubia

AU - Monlux, Roy

AU - Isaac, Michael

AU - Cosand, Beverly

AU - Swift, Shari

AU - Clark, Darrl

AU - Shadix, Vicki

AU - Krachmer, Jay H.

AU - Hardy, Robert J.

AU - McCulley, James P

AU - Stark, Walter J.

AU - Thoft, Richard A.

AU - Aquavella, James V.

AU - Baum, Jules L.

AU - Sugar, Joel

AU - Ware, James

AU - Lynn, Michale J.

AU - Geller, Ronald G.

AU - Helmsen, Ralph J.

N1 - Funding Information: Funded by the National Eye Institute Grant Nos. EY03761, EY03756, EY03755, EY03764, EY03753, EY03751, EY03767, EY04176, EY03752, and EY03765.

PY - 1985

Y1 - 1985

N2 - The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.

AB - The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center, self-controlled clinical trial of a standardized technique of radial keratotomy in 435 patients who had physiologic myopia with a preoperative refraction between −2.00 and −8.00 diopters. The surgical technique consisted of eight incisions using a diamond micrometer knife with blade length determined by intraoperative ultrasonic pachymetry and the diameter of central clear zone determined by preoperative refraction. At one year after surgery, myopia was reduced in all eyes; 60% were within ±1.00 diopter of emmetropia; 30% were undercorrected and 10% were overcorrected by more than 1.00 diopter (range of refraction, −4.25 to +3.38 D). Uncorrected visual acuity was 20/40 or better in 78% of eyes. The operation was most effective in eyes with a refraction between −2.00 and −4.25 diopters. Thirteen percent of patients lost one or two Snellen lines of best corrected visual acuity. However, all but three eyes could be corrected to 20/20. Ten percent of patients increased astigmatism more than 1.00 diopter. Disabling glare was not detected with a clinical glare tester, but three patients reduced their driving at night because of glare. Between six months and one year, the refraction changed by >0.50 diopters in 19% of eyes.

KW - astigmatism

KW - clinical trial

KW - cornea

KW - glare

KW - myopia

KW - radial keratotomy

KW - refractive keratoplasty

UR - http://www.scopus.com/inward/record.url?scp=0021986127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021986127&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(85)34054-X

DO - 10.1016/S0161-6420(85)34054-X

M3 - Article

C2 - 3885128

AN - SCOPUS:0021986127

SN - 0161-6420

VL - 92

SP - 177

EP - 198

JO - Ophthalmology

JF - Ophthalmology

IS - 2

ER -

Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study One Year After Surgery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this