Results of treatment with Telmisartan-Amlodipine in hypertensive patients

Thomas W. Littlejohn; Claudio R. Majul; Rafael Olvera; Mary Seeber; Maureen Kobe; Robert Guthrie; Wille Oigman; H. Baglivo; M. Bendersky; E. Kuschnir; P. Rodriguez; A. Villamil; J. Felicio; P. Jardim; O. Kohlman; D. Mion; M. Alpizar; R. Alvarado; J. Illescas; A. Meaney; J. Parra; R. Peralta; I. Rodriguez; H. Sanchez; S. Trevethan; D. Bernhardi; A. Briel; S. Chetty; E. Janari; J. Jurgens; C. Kahanowitz; D. Lakha; H. Makan; I. Mitha; P. Nel; P. Patel; Z. Vawda; N. Wellington; J. Agaiby; J. Anderson; G. Balaji; H. Bays; N. Bertini; W. Bestermann; K. Blaze; A. Borge; J. Boscia; T. Brobyn; J. Brodnan; V. Brown; T. Cavalieri; C. Chappel; A. Chen; D. Cheung; S. Christensen; S. Chrysant; C. Cooper; T. Copeland; C. De Busk; D. DeSantis; B. Douglas; J. Ervin; P. Fiacco; T. Fiel; J. George; L. Gilderman; R. Gilman; III Glover; A. Goetsch; R. Graf; A. Graff; M. Graves; J. Gutmann; C. Hall; W. Harper; D. Henry; H. Hidalgo; J. Holland; D. Honeycutt; C. Johnson; A. Khan; B. Khan; P. Klaassen; M. Kozinn; S. Kreis; K. Layne; J. Lee; A. Lewin; C. S. Liang; L. Ligon; T. Linder; R. Lipetz; M. Lucas; R. Marple; J. Meli; C. Mello; R. Middleton; S. Mion-Bet; K. Mootoo; A. Murray; J. Naidu; P. Narayan; J. Navarro; J. Neutel; A. Niederman; R. Noble; A. Patron; F. Phillips; W. Pleskow; H. Punzi; G. Raad; T. Raoof; Philip Raskin; A. Razzetti; L. Reed; H. Resnick; J. Schmidt; R. Schreiman; D. Schumacher; M. Seidner; K. Self; G. Serfer; W. Shapiro; J. Silverfield; S. Slabic; R. Sockolov; J. Sparks; R. Struble; C. Thompson; P. Toth; T. Treimer; P. Vrooman; D. Webster; G. Willis; S. Willsie; D. Wright; S. Yates; Karen Shannon; Steven Koval; Ashish Singh

doi:10.1111/j.1751-7176.2009.00098.x

Results of treatment with Telmisartan-Amlodipine in hypertensive patients

Thomas W. Littlejohn, Claudio R. Majul, Rafael Olvera, Mary Seeber, Maureen Kobe, Robert Guthrie, Wille Oigman, H. Baglivo, M. Bendersky, E. Kuschnir, P. Rodriguez, A. Villamil, J. Felicio, P. Jardim, O. Kohlman, D. Mion, M. Alpizar, R. Alvarado, J. Illescas, A. MeaneyJ. Parra, R. Peralta, I. Rodriguez, H. Sanchez, S. Trevethan, D. Bernhardi, A. Briel, S. Chetty, E. Janari, J. Jurgens, C. Kahanowitz, D. Lakha, H. Makan, I. Mitha, P. Nel, P. Patel, Z. Vawda, N. Wellington, J. Agaiby, J. Anderson, G. Balaji, H. Bays, N. Bertini, W. Bestermann, K. Blaze, A. Borge, J. Boscia, T. Brobyn, J. Brodnan, V. Brown, T. Cavalieri, C. Chappel, A. Chen, D. Cheung, S. Christensen, S. Chrysant, C. Cooper, T. Copeland, C. De Busk, D. DeSantis, B. Douglas, J. Ervin, P. Fiacco, T. Fiel, J. George, L. Gilderman, R. Gilman, III Glover, A. Goetsch, R. Graf, A. Graff, M. Graves, J. Gutmann, C. Hall, W. Harper, D. Henry, H. Hidalgo, J. Holland, D. Honeycutt, C. Johnson, A. Khan, B. Khan, P. Klaassen, M. Kozinn, S. Kreis, K. Layne, J. Lee, A. Lewin, C. S. Liang, L. Ligon, T. Linder, R. Lipetz, M. Lucas, R. Marple, J. Meli, C. Mello, R. Middleton, S. Mion-Bet, K. Mootoo, A. Murray, J. Naidu, P. Narayan, J. Navarro, J. Neutel, A. Niederman, R. Noble, A. Patron, F. Phillips, W. Pleskow, H. Punzi, G. Raad, T. Raoof, Philip Raskin, A. Razzetti, L. Reed, H. Resnick, J. Schmidt, R. Schreiman, D. Schumacher, M. Seidner, K. Self, G. Serfer, W. Shapiro, J. Silverfield, S. Slabic, R. Sockolov, J. Sparks, R. Struble, C. Thompson, P. Toth, T. Treimer, P. Vrooman, D. Webster, G. Willis, S. Willsie, D. Wright, S. Yates, Karen Shannon, Steven Koval, Ashish Singh

Research output: Contribution to journal › Article › peer-review

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Abstract

This randomized 4 × 4 factorial study determined the efficacy and safety of telmisartan (T) plus amlodipine (A) in hypertensive patients. Adults (N = 1461) with stage 1 or 2 hypertension (baseline blood pressure [BP]: 153.2[12.1]/101.7[4.3] mm Hg) were randomized to 1 of 16 treatment groups with T 0, 20, 40, 80 mg and A 0, 2.5, 5, 10 mg for 8weeks. In-clinic BP reductions were greater with combination therapy than respective monotherapies. The greatest least-square mean systolic/ diastolic BP reductions were observed with T80 mg plus A10 mg (-26.4/ -20.1 mm Hg; P < .05 compared with both monotherapies). BP control was also greatest in the T80-mg plus A10-mg group (76.5% [overall control] and 85.3% [diastolic BP control]), and BP response rates >90% with this combination. Peripheral edema was most common in the A10-mg group (17.8%); however, this rate was notably lower when A was used in combination with T: 11.4% (T20/A10), 6.2% (T40/A10), and 11.3% (T80/ A10).

Original language	English (US)
Pages (from-to)	207-213
Number of pages	7
Journal	Journal of Clinical Hypertension
Volume	11
Issue number	4
DOIs	https://doi.org/10.1111/j.1751-7176.2009.00098.x
State	Published - 2009

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

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10.1111/j.1751-7176.2009.00098.x

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Littlejohn, T. W., Majul, C. R., Olvera, R., Seeber, M., Kobe, M., Guthrie, R., Oigman, W., Baglivo, H., Bendersky, M., Kuschnir, E., Rodriguez, P., Villamil, A., Felicio, J., Jardim, P., Kohlman, O., Mion, D., Alpizar, M., Alvarado, R., Illescas, J., ... Singh, A. (2009). Results of treatment with Telmisartan-Amlodipine in hypertensive patients. Journal of Clinical Hypertension, 11(4), 207-213. https://doi.org/10.1111/j.1751-7176.2009.00098.x

Littlejohn, TW, Majul, CR, Olvera, R, Seeber, M, Kobe, M, Guthrie, R, Oigman, W, Baglivo, H, Bendersky, M, Kuschnir, E, Rodriguez, P, Villamil, A, Felicio, J, Jardim, P, Kohlman, O, Mion, D, Alpizar, M, Alvarado, R, Illescas, J, Meaney, A, Parra, J, Peralta, R, Rodriguez, I, Sanchez, H, Trevethan, S, Bernhardi, D, Briel, A, Chetty, S, Janari, E, Jurgens, J, Kahanowitz, C, Lakha, D, Makan, H, Mitha, I, Nel, P, Patel, P, Vawda, Z, Wellington, N, Agaiby, J, Anderson, J, Balaji, G, Bays, H, Bertini, N, Bestermann, W, Blaze, K, Borge, A, Boscia, J, Brobyn, T, Brodnan, J, Brown, V, Cavalieri, T, Chappel, C, Chen, A, Cheung, D, Christensen, S, Chrysant, S, Cooper, C, Copeland, T, De Busk, C, DeSantis, D, Douglas, B, Ervin, J, Fiacco, P, Fiel, T, George, J, Gilderman, L, Gilman, R, Glover, III, Goetsch, A, Graf, R, Graff, A, Graves, M, Gutmann, J, Hall, C, Harper, W, Henry, D, Hidalgo, H, Holland, J, Honeycutt, D, Johnson, C, Khan, A, Khan, B, Klaassen, P, Kozinn, M, Kreis, S, Layne, K, Lee, J, Lewin, A, Liang, CS, Ligon, L, Linder, T, Lipetz, R, Lucas, M, Marple, R, Meli, J, Mello, C, Middleton, R, Mion-Bet, S, Mootoo, K, Murray, A, Naidu, J, Narayan, P, Navarro, J, Neutel, J, Niederman, A, Noble, R, Patron, A, Phillips, F, Pleskow, W, Punzi, H, Raad, G, Raoof, T, Raskin, P, Razzetti, A, Reed, L, Resnick, H, Schmidt, J, Schreiman, R, Schumacher, D, Seidner, M, Self, K, Serfer, G, Shapiro, W, Silverfield, J, Slabic, S, Sockolov, R, Sparks, J, Struble, R, Thompson, C, Toth, P, Treimer, T, Vrooman, P, Webster, D, Willis, G, Willsie, S, Wright, D, Yates, S, Shannon, K, Koval, S & Singh, A 2009, 'Results of treatment with Telmisartan-Amlodipine in hypertensive patients', Journal of Clinical Hypertension, vol. 11, no. 4, pp. 207-213. https://doi.org/10.1111/j.1751-7176.2009.00098.x

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title = "Results of treatment with Telmisartan-Amlodipine in hypertensive patients",

abstract = "This randomized 4 × 4 factorial study determined the efficacy and safety of telmisartan (T) plus amlodipine (A) in hypertensive patients. Adults (N = 1461) with stage 1 or 2 hypertension (baseline blood pressure [BP]: 153.2[12.1]/101.7[4.3] mm Hg) were randomized to 1 of 16 treatment groups with T 0, 20, 40, 80 mg and A 0, 2.5, 5, 10 mg for 8weeks. In-clinic BP reductions were greater with combination therapy than respective monotherapies. The greatest least-square mean systolic/ diastolic BP reductions were observed with T80 mg plus A10 mg (-26.4/ -20.1 mm Hg; P < .05 compared with both monotherapies). BP control was also greatest in the T80-mg plus A10-mg group (76.5% [overall control] and 85.3% [diastolic BP control]), and BP response rates >90% with this combination. Peripheral edema was most common in the A10-mg group (17.8%); however, this rate was notably lower when A was used in combination with T: 11.4% (T20/A10), 6.2% (T40/A10), and 11.3% (T80/ A10).",

author = "Littlejohn, {Thomas W.} and Majul, {Claudio R.} and Rafael Olvera and Mary Seeber and Maureen Kobe and Robert Guthrie and Wille Oigman and H. Baglivo and M. Bendersky and E. Kuschnir and P. Rodriguez and A. Villamil and J. Felicio and P. Jardim and O. Kohlman and D. Mion and M. Alpizar and R. Alvarado and J. Illescas and A. Meaney and J. Parra and R. Peralta and I. Rodriguez and H. Sanchez and S. Trevethan and D. Bernhardi and A. Briel and S. Chetty and E. Janari and J. Jurgens and C. Kahanowitz and D. Lakha and H. Makan and I. Mitha and P. Nel and P. Patel and Z. Vawda and N. Wellington and J. Agaiby and J. Anderson and G. Balaji and H. Bays and N. Bertini and W. Bestermann and K. Blaze and A. Borge and J. Boscia and T. Brobyn and J. Brodnan and V. Brown and T. Cavalieri and C. Chappel and A. Chen and D. Cheung and S. Christensen and S. Chrysant and C. Cooper and T. Copeland and {De Busk}, C. and D. DeSantis and B. Douglas and J. Ervin and P. Fiacco and T. Fiel and J. George and L. Gilderman and R. Gilman and III Glover and A. Goetsch and R. Graf and A. Graff and M. Graves and J. Gutmann and C. Hall and W. Harper and D. Henry and H. Hidalgo and J. Holland and D. Honeycutt and C. Johnson and A. Khan and B. Khan and P. Klaassen and M. Kozinn and S. Kreis and K. Layne and J. Lee and A. Lewin and Liang, {C. S.} and L. Ligon and T. Linder and R. Lipetz and M. Lucas and R. Marple and J. Meli and C. Mello and R. Middleton and S. Mion-Bet and K. Mootoo and A. Murray and J. Naidu and P. Narayan and J. Navarro and J. Neutel and A. Niederman and R. Noble and A. Patron and F. Phillips and W. Pleskow and H. Punzi and G. Raad and T. Raoof and Philip Raskin and A. Razzetti and L. Reed and H. Resnick and J. Schmidt and R. Schreiman and D. Schumacher and M. Seidner and K. Self and G. Serfer and W. Shapiro and J. Silverfield and S. Slabic and R. Sockolov and J. Sparks and R. Struble and C. Thompson and P. Toth and T. Treimer and P. Vrooman and D. Webster and G. Willis and S. Willsie and D. Wright and S. Yates and Karen Shannon and Steven Koval and Ashish Singh",

year = "2009",

doi = "10.1111/j.1751-7176.2009.00098.x",

language = "English (US)",

volume = "11",

pages = "207--213",

journal = "Journal of Clinical Hypertension",

issn = "1524-6175",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

TY - JOUR

T1 - Results of treatment with Telmisartan-Amlodipine in hypertensive patients

AU - Littlejohn, Thomas W.

AU - Majul, Claudio R.

AU - Olvera, Rafael

AU - Seeber, Mary

AU - Kobe, Maureen

AU - Guthrie, Robert

AU - Oigman, Wille

AU - Baglivo, H.

AU - Bendersky, M.

AU - Kuschnir, E.

AU - Rodriguez, P.

AU - Villamil, A.

AU - Felicio, J.

AU - Jardim, P.

AU - Kohlman, O.

AU - Mion, D.

AU - Alpizar, M.

AU - Alvarado, R.

AU - Illescas, J.

AU - Meaney, A.

AU - Parra, J.

AU - Peralta, R.

AU - Rodriguez, I.

AU - Sanchez, H.

AU - Trevethan, S.

AU - Bernhardi, D.

AU - Briel, A.

AU - Chetty, S.

AU - Janari, E.

AU - Jurgens, J.

AU - Kahanowitz, C.

AU - Lakha, D.

AU - Makan, H.

AU - Mitha, I.

AU - Nel, P.

AU - Patel, P.

AU - Vawda, Z.

AU - Wellington, N.

AU - Agaiby, J.

AU - Anderson, J.

AU - Balaji, G.

AU - Bays, H.

AU - Bertini, N.

AU - Bestermann, W.

AU - Blaze, K.

AU - Borge, A.

AU - Boscia, J.

AU - Brobyn, T.

AU - Brodnan, J.

AU - Brown, V.

AU - Cavalieri, T.

AU - Chappel, C.

AU - Chen, A.

AU - Cheung, D.

AU - Christensen, S.

AU - Chrysant, S.

AU - Cooper, C.

AU - Copeland, T.

AU - De Busk, C.

AU - DeSantis, D.

AU - Douglas, B.

AU - Ervin, J.

AU - Fiacco, P.

AU - Fiel, T.

AU - George, J.

AU - Gilderman, L.

AU - Gilman, R.

AU - Glover, III

AU - Goetsch, A.

AU - Graf, R.

AU - Graff, A.

AU - Graves, M.

AU - Gutmann, J.

AU - Hall, C.

AU - Harper, W.

AU - Henry, D.

AU - Hidalgo, H.

AU - Holland, J.

AU - Honeycutt, D.

AU - Johnson, C.

AU - Khan, A.

AU - Khan, B.

AU - Klaassen, P.

AU - Kozinn, M.

AU - Kreis, S.

AU - Layne, K.

AU - Lee, J.

AU - Lewin, A.

AU - Liang, C. S.

AU - Ligon, L.

AU - Linder, T.

AU - Lipetz, R.

AU - Lucas, M.

AU - Marple, R.

AU - Meli, J.

AU - Mello, C.

AU - Middleton, R.

AU - Mion-Bet, S.

AU - Mootoo, K.

AU - Murray, A.

AU - Naidu, J.

AU - Narayan, P.

AU - Navarro, J.

AU - Neutel, J.

AU - Niederman, A.

AU - Noble, R.

AU - Patron, A.

AU - Phillips, F.

AU - Pleskow, W.

AU - Punzi, H.

AU - Raad, G.

AU - Raoof, T.

AU - Raskin, Philip

AU - Razzetti, A.

AU - Reed, L.

AU - Resnick, H.

AU - Schmidt, J.

AU - Schreiman, R.

AU - Schumacher, D.

AU - Seidner, M.

AU - Self, K.

AU - Serfer, G.

AU - Shapiro, W.

AU - Silverfield, J.

AU - Slabic, S.

AU - Sockolov, R.

AU - Sparks, J.

AU - Struble, R.

AU - Thompson, C.

AU - Toth, P.

AU - Treimer, T.

AU - Vrooman, P.

AU - Webster, D.

AU - Willis, G.

AU - Willsie, S.

AU - Wright, D.

AU - Yates, S.

AU - Shannon, Karen

AU - Koval, Steven

AU - Singh, Ashish

PY - 2009

Y1 - 2009

N2 - This randomized 4 × 4 factorial study determined the efficacy and safety of telmisartan (T) plus amlodipine (A) in hypertensive patients. Adults (N = 1461) with stage 1 or 2 hypertension (baseline blood pressure [BP]: 153.2[12.1]/101.7[4.3] mm Hg) were randomized to 1 of 16 treatment groups with T 0, 20, 40, 80 mg and A 0, 2.5, 5, 10 mg for 8weeks. In-clinic BP reductions were greater with combination therapy than respective monotherapies. The greatest least-square mean systolic/ diastolic BP reductions were observed with T80 mg plus A10 mg (-26.4/ -20.1 mm Hg; P < .05 compared with both monotherapies). BP control was also greatest in the T80-mg plus A10-mg group (76.5% [overall control] and 85.3% [diastolic BP control]), and BP response rates >90% with this combination. Peripheral edema was most common in the A10-mg group (17.8%); however, this rate was notably lower when A was used in combination with T: 11.4% (T20/A10), 6.2% (T40/A10), and 11.3% (T80/ A10).

AB - This randomized 4 × 4 factorial study determined the efficacy and safety of telmisartan (T) plus amlodipine (A) in hypertensive patients. Adults (N = 1461) with stage 1 or 2 hypertension (baseline blood pressure [BP]: 153.2[12.1]/101.7[4.3] mm Hg) were randomized to 1 of 16 treatment groups with T 0, 20, 40, 80 mg and A 0, 2.5, 5, 10 mg for 8weeks. In-clinic BP reductions were greater with combination therapy than respective monotherapies. The greatest least-square mean systolic/ diastolic BP reductions were observed with T80 mg plus A10 mg (-26.4/ -20.1 mm Hg; P < .05 compared with both monotherapies). BP control was also greatest in the T80-mg plus A10-mg group (76.5% [overall control] and 85.3% [diastolic BP control]), and BP response rates >90% with this combination. Peripheral edema was most common in the A10-mg group (17.8%); however, this rate was notably lower when A was used in combination with T: 11.4% (T20/A10), 6.2% (T40/A10), and 11.3% (T80/ A10).

UR - http://www.scopus.com/inward/record.url?scp=65449181110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65449181110&partnerID=8YFLogxK

U2 - 10.1111/j.1751-7176.2009.00098.x

DO - 10.1111/j.1751-7176.2009.00098.x

M3 - Article

C2 - 19614805

AN - SCOPUS:65449181110

SN - 1524-6175

VL - 11

SP - 207

EP - 213

JO - Journal of Clinical Hypertension

JF - Journal of Clinical Hypertension

IS - 4

ER -

Results of treatment with Telmisartan-Amlodipine in hypertensive patients

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