Resuscitation-induced gut edema and intestinal dysfunction

Stacey D. Moore-Olufemi, Hasan Xue, Bashir O. Attuwaybi, Uwe Fischer, Y. Harari, D. H. Oliver, Norman Weisbrodt, Steven J. Allen, Frederick A. Moore, Randolph Stewart, Glen A. Laine, Charles S. Cox

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Background: Mesenteric venous hypertension and subsequent gut edema play a pivotal role in the development of intra-abdominal hypertension. Although gut edema is one cause of intra-abdominal hypertension, its impact on gut function is unknown. The purpose of this study was to create a model of acute hydrostatic gut edema and to evaluate its effect on gut motility and barrier function. Methods: The first study, group A, evaluated the effect of gut edema on transit over time using 20 mL/kg 0.9% saline. The second study, group B, focused on the 12-hour time period using 80 mL/kg 0.9% saline. Rats were randomized to superior mesenteric vein partial occlusion (venous hypertension) or sham surgery. At 6, 12, and 24 hours, group A underwent intestinal transit and tissue water weight measurements. At 12 hours, group B underwent tissue water, transit, ileal permeability and resistance, lactate and myeloperoxidase activity, and mucosal injury measurements. Results: Venous hypertension with fluid resuscitation caused acute hydrostatic gut edema, delayed intestinal transit, increased mucosal permeability to macromolecules, and decreased tissue resistance over time. Mucosal injury was minimal in mesenteric venous hypertension. Conclusion: Acute mesenteric venous hypertension and resuscitation-induced gut edema, in the absence of ischemia/reperfusion injury, is associated with delayed intestinal transit and altered gut barrier function.

Original languageEnglish (US)
Pages (from-to)264-270
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume58
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Resuscitation
Edema
Hypertension
Intra-Abdominal Hypertension
Permeability
Mesenteric Veins
Water
Wounds and Injuries
Reperfusion Injury
Peroxidase
Lactic Acid
Weights and Measures

Keywords

  • Gut edema
  • Intestinal transit
  • Mesenteric venous hypertension

ASJC Scopus subject areas

  • Surgery

Cite this

Resuscitation-induced gut edema and intestinal dysfunction. / Moore-Olufemi, Stacey D.; Xue, Hasan; Attuwaybi, Bashir O.; Fischer, Uwe; Harari, Y.; Oliver, D. H.; Weisbrodt, Norman; Allen, Steven J.; Moore, Frederick A.; Stewart, Randolph; Laine, Glen A.; Cox, Charles S.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 58, No. 2, 02.2005, p. 264-270.

Research output: Contribution to journalArticle

Moore-Olufemi, SD, Xue, H, Attuwaybi, BO, Fischer, U, Harari, Y, Oliver, DH, Weisbrodt, N, Allen, SJ, Moore, FA, Stewart, R, Laine, GA & Cox, CS 2005, 'Resuscitation-induced gut edema and intestinal dysfunction', Journal of Trauma - Injury, Infection and Critical Care, vol. 58, no. 2, pp. 264-270. https://doi.org/10.1097/01.TA.0000133571.64393.D2
Moore-Olufemi, Stacey D. ; Xue, Hasan ; Attuwaybi, Bashir O. ; Fischer, Uwe ; Harari, Y. ; Oliver, D. H. ; Weisbrodt, Norman ; Allen, Steven J. ; Moore, Frederick A. ; Stewart, Randolph ; Laine, Glen A. ; Cox, Charles S. / Resuscitation-induced gut edema and intestinal dysfunction. In: Journal of Trauma - Injury, Infection and Critical Care. 2005 ; Vol. 58, No. 2. pp. 264-270.
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AU - Oliver, D. H.

AU - Weisbrodt, Norman

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AB - Background: Mesenteric venous hypertension and subsequent gut edema play a pivotal role in the development of intra-abdominal hypertension. Although gut edema is one cause of intra-abdominal hypertension, its impact on gut function is unknown. The purpose of this study was to create a model of acute hydrostatic gut edema and to evaluate its effect on gut motility and barrier function. Methods: The first study, group A, evaluated the effect of gut edema on transit over time using 20 mL/kg 0.9% saline. The second study, group B, focused on the 12-hour time period using 80 mL/kg 0.9% saline. Rats were randomized to superior mesenteric vein partial occlusion (venous hypertension) or sham surgery. At 6, 12, and 24 hours, group A underwent intestinal transit and tissue water weight measurements. At 12 hours, group B underwent tissue water, transit, ileal permeability and resistance, lactate and myeloperoxidase activity, and mucosal injury measurements. Results: Venous hypertension with fluid resuscitation caused acute hydrostatic gut edema, delayed intestinal transit, increased mucosal permeability to macromolecules, and decreased tissue resistance over time. Mucosal injury was minimal in mesenteric venous hypertension. Conclusion: Acute mesenteric venous hypertension and resuscitation-induced gut edema, in the absence of ischemia/reperfusion injury, is associated with delayed intestinal transit and altered gut barrier function.

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