Retinal architecture and mfERG: Optic nerve head component response characteristics in MS

Zane S. Schnurman, Teresa C. Frohman, Shin C Beh, Darrel Conger, Amy Conger, Shiv Saidha, Steven Galetta, Peter A. Calabresi, Ari J. Green, Laura J. Balcer, Elliot Frohman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To describe a novel neurophysiologic signature of the retinal ganglion cell and to elucidate its relationship to abnormalities in validated structural and functional measures of the visual system. Methods: We used multifocal electroretinogram-generated optic nerve head component (ONHC) responses from normal subjects (n = 18), patients with multiple sclerosis (MS) (n = 18), and those with glaucoma (n = 3). We then characterized the relationship between ONHC response abnormalities and performance on low-contrast visual acuity, multifocal visual-evoked potential-induced cortical responses, and average and quadrant retinal nerve fiber layer (RNFL) thicknesses, as measured by spectral-domain optical coherence tomography. Results: Compared with the eyes of normal subjects, the eyes of patients with MS exhibited an increased number of abnormal or absent ONHC responses (p < 0.0001). For every 7-letter reduction in low-contrast letter acuity, there were corresponding 4.6 abnormal ONHC responses at 2.5% contrast (p < 0.0001) and 6.6 abnormalities at the 1.25% contrast level (p < 0.0001). Regarding average RNFL thickness, for each 10-μm thickness reduction, we correspondingly observed 6.8 abnormal ONHC responses (p = 0.0002). The most robust association was between RNFL thinning in the temporal quadrant and ONHC response abnormalities (p < 0.0001). Conclusion: Further characterization of ONHC abnormalities (those that are reversible and irreversible) may contribute to the development of novel neurotherapeutic strategies aimed at achieving neuroprotective, and perhaps even neurorestorative, effects in disorders that target the CNS in general, and MS in particular.

Original languageEnglish (US)
Pages (from-to)1888-1896
Number of pages9
JournalNeurology
Volume82
Issue number21
DOIs
StatePublished - May 27 2014

Fingerprint

Optic Disk
Multiple Sclerosis
Nerve Fibers
Visual Evoked Potentials
Retinal Ganglion Cells
Optical Coherence Tomography
Nerve
Optics
Glaucoma
Visual Acuity

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Retinal architecture and mfERG : Optic nerve head component response characteristics in MS. / Schnurman, Zane S.; Frohman, Teresa C.; Beh, Shin C; Conger, Darrel; Conger, Amy; Saidha, Shiv; Galetta, Steven; Calabresi, Peter A.; Green, Ari J.; Balcer, Laura J.; Frohman, Elliot.

In: Neurology, Vol. 82, No. 21, 27.05.2014, p. 1888-1896.

Research output: Contribution to journalArticle

Schnurman, ZS, Frohman, TC, Beh, SC, Conger, D, Conger, A, Saidha, S, Galetta, S, Calabresi, PA, Green, AJ, Balcer, LJ & Frohman, E 2014, 'Retinal architecture and mfERG: Optic nerve head component response characteristics in MS', Neurology, vol. 82, no. 21, pp. 1888-1896. https://doi.org/10.1212/WNL.0000000000000447
Schnurman, Zane S. ; Frohman, Teresa C. ; Beh, Shin C ; Conger, Darrel ; Conger, Amy ; Saidha, Shiv ; Galetta, Steven ; Calabresi, Peter A. ; Green, Ari J. ; Balcer, Laura J. ; Frohman, Elliot. / Retinal architecture and mfERG : Optic nerve head component response characteristics in MS. In: Neurology. 2014 ; Vol. 82, No. 21. pp. 1888-1896.
@article{3b4bbb7af345445baf7422abc5bcd949,
title = "Retinal architecture and mfERG: Optic nerve head component response characteristics in MS",
abstract = "Objective: To describe a novel neurophysiologic signature of the retinal ganglion cell and to elucidate its relationship to abnormalities in validated structural and functional measures of the visual system. Methods: We used multifocal electroretinogram-generated optic nerve head component (ONHC) responses from normal subjects (n = 18), patients with multiple sclerosis (MS) (n = 18), and those with glaucoma (n = 3). We then characterized the relationship between ONHC response abnormalities and performance on low-contrast visual acuity, multifocal visual-evoked potential-induced cortical responses, and average and quadrant retinal nerve fiber layer (RNFL) thicknesses, as measured by spectral-domain optical coherence tomography. Results: Compared with the eyes of normal subjects, the eyes of patients with MS exhibited an increased number of abnormal or absent ONHC responses (p < 0.0001). For every 7-letter reduction in low-contrast letter acuity, there were corresponding 4.6 abnormal ONHC responses at 2.5{\%} contrast (p < 0.0001) and 6.6 abnormalities at the 1.25{\%} contrast level (p < 0.0001). Regarding average RNFL thickness, for each 10-μm thickness reduction, we correspondingly observed 6.8 abnormal ONHC responses (p = 0.0002). The most robust association was between RNFL thinning in the temporal quadrant and ONHC response abnormalities (p < 0.0001). Conclusion: Further characterization of ONHC abnormalities (those that are reversible and irreversible) may contribute to the development of novel neurotherapeutic strategies aimed at achieving neuroprotective, and perhaps even neurorestorative, effects in disorders that target the CNS in general, and MS in particular.",
author = "Schnurman, {Zane S.} and Frohman, {Teresa C.} and Beh, {Shin C} and Darrel Conger and Amy Conger and Shiv Saidha and Steven Galetta and Calabresi, {Peter A.} and Green, {Ari J.} and Balcer, {Laura J.} and Elliot Frohman",
year = "2014",
month = "5",
day = "27",
doi = "10.1212/WNL.0000000000000447",
language = "English (US)",
volume = "82",
pages = "1888--1896",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "21",

}

TY - JOUR

T1 - Retinal architecture and mfERG

T2 - Optic nerve head component response characteristics in MS

AU - Schnurman, Zane S.

AU - Frohman, Teresa C.

AU - Beh, Shin C

AU - Conger, Darrel

AU - Conger, Amy

AU - Saidha, Shiv

AU - Galetta, Steven

AU - Calabresi, Peter A.

AU - Green, Ari J.

AU - Balcer, Laura J.

AU - Frohman, Elliot

PY - 2014/5/27

Y1 - 2014/5/27

N2 - Objective: To describe a novel neurophysiologic signature of the retinal ganglion cell and to elucidate its relationship to abnormalities in validated structural and functional measures of the visual system. Methods: We used multifocal electroretinogram-generated optic nerve head component (ONHC) responses from normal subjects (n = 18), patients with multiple sclerosis (MS) (n = 18), and those with glaucoma (n = 3). We then characterized the relationship between ONHC response abnormalities and performance on low-contrast visual acuity, multifocal visual-evoked potential-induced cortical responses, and average and quadrant retinal nerve fiber layer (RNFL) thicknesses, as measured by spectral-domain optical coherence tomography. Results: Compared with the eyes of normal subjects, the eyes of patients with MS exhibited an increased number of abnormal or absent ONHC responses (p < 0.0001). For every 7-letter reduction in low-contrast letter acuity, there were corresponding 4.6 abnormal ONHC responses at 2.5% contrast (p < 0.0001) and 6.6 abnormalities at the 1.25% contrast level (p < 0.0001). Regarding average RNFL thickness, for each 10-μm thickness reduction, we correspondingly observed 6.8 abnormal ONHC responses (p = 0.0002). The most robust association was between RNFL thinning in the temporal quadrant and ONHC response abnormalities (p < 0.0001). Conclusion: Further characterization of ONHC abnormalities (those that are reversible and irreversible) may contribute to the development of novel neurotherapeutic strategies aimed at achieving neuroprotective, and perhaps even neurorestorative, effects in disorders that target the CNS in general, and MS in particular.

AB - Objective: To describe a novel neurophysiologic signature of the retinal ganglion cell and to elucidate its relationship to abnormalities in validated structural and functional measures of the visual system. Methods: We used multifocal electroretinogram-generated optic nerve head component (ONHC) responses from normal subjects (n = 18), patients with multiple sclerosis (MS) (n = 18), and those with glaucoma (n = 3). We then characterized the relationship between ONHC response abnormalities and performance on low-contrast visual acuity, multifocal visual-evoked potential-induced cortical responses, and average and quadrant retinal nerve fiber layer (RNFL) thicknesses, as measured by spectral-domain optical coherence tomography. Results: Compared with the eyes of normal subjects, the eyes of patients with MS exhibited an increased number of abnormal or absent ONHC responses (p < 0.0001). For every 7-letter reduction in low-contrast letter acuity, there were corresponding 4.6 abnormal ONHC responses at 2.5% contrast (p < 0.0001) and 6.6 abnormalities at the 1.25% contrast level (p < 0.0001). Regarding average RNFL thickness, for each 10-μm thickness reduction, we correspondingly observed 6.8 abnormal ONHC responses (p = 0.0002). The most robust association was between RNFL thinning in the temporal quadrant and ONHC response abnormalities (p < 0.0001). Conclusion: Further characterization of ONHC abnormalities (those that are reversible and irreversible) may contribute to the development of novel neurotherapeutic strategies aimed at achieving neuroprotective, and perhaps even neurorestorative, effects in disorders that target the CNS in general, and MS in particular.

UR - http://www.scopus.com/inward/record.url?scp=84902143593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902143593&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000000447

DO - 10.1212/WNL.0000000000000447

M3 - Article

C2 - 24789865

AN - SCOPUS:84902143593

VL - 82

SP - 1888

EP - 1896

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 21

ER -