Retinal damage and vision loss in African American multiple sclerosis patients

Dorlan J. Kimbrough, Elias S. Sotirchos, James A. Wilson, Omar Al-Louzi, Amy Conger, Darrel Conger, Teresa C. Frohman, Shiv Saidha, Ari J. Green, Elliot Frohman, Laura J. Balcer, Peter A. Calabresi

Research output: Contribution to journalArticle

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Abstract

Objective: To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients. Methods: A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high- and low-contrast visual acuity (HCVA and LCVA) and high-definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self-identified AA and CA ancestry. Results: In HCs, baseline peripapillary retinal nerve fiber layer (RNFL) thickness was 6.1μm greater in AAs (p50.047), whereas ganglion cell/inner plexiform layer (GCIP) thickness did not differ by race. In MS patients, baseline RNFL did not differ by race, and GCIP was 3.98μm thinner in AAs (p = 0.004). AAs had faster RNFL and GCIP thinning rates compared to CAs (p = 0.004 and p = 0.046, respectively). AA MS patients had lower baseline HCVA (p 5 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012). Interpretation: This multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self-identified AA ancestry is associated with worse MS-related visual disability, particularly in the context of an AON history, suggesting a more aggressive inflammatory disease course among AA MS patients or a subpopulation therein.

Original languageEnglish (US)
Pages (from-to)228-236
Number of pages9
JournalAnnals of Neurology
Volume77
Issue number2
DOIs
StatePublished - Feb 1 2015

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African Americans
Multiple Sclerosis
Nerve Fibers
Ganglia
Optic Neuritis
Vision Disorders
Optical Coherence Tomography
Visual Acuity
Healthy Volunteers
History

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Kimbrough, D. J., Sotirchos, E. S., Wilson, J. A., Al-Louzi, O., Conger, A., Conger, D., ... Calabresi, P. A. (2015). Retinal damage and vision loss in African American multiple sclerosis patients. Annals of Neurology, 77(2), 228-236. https://doi.org/10.1002/ana.24308

Retinal damage and vision loss in African American multiple sclerosis patients. / Kimbrough, Dorlan J.; Sotirchos, Elias S.; Wilson, James A.; Al-Louzi, Omar; Conger, Amy; Conger, Darrel; Frohman, Teresa C.; Saidha, Shiv; Green, Ari J.; Frohman, Elliot; Balcer, Laura J.; Calabresi, Peter A.

In: Annals of Neurology, Vol. 77, No. 2, 01.02.2015, p. 228-236.

Research output: Contribution to journalArticle

Kimbrough, DJ, Sotirchos, ES, Wilson, JA, Al-Louzi, O, Conger, A, Conger, D, Frohman, TC, Saidha, S, Green, AJ, Frohman, E, Balcer, LJ & Calabresi, PA 2015, 'Retinal damage and vision loss in African American multiple sclerosis patients', Annals of Neurology, vol. 77, no. 2, pp. 228-236. https://doi.org/10.1002/ana.24308
Kimbrough DJ, Sotirchos ES, Wilson JA, Al-Louzi O, Conger A, Conger D et al. Retinal damage and vision loss in African American multiple sclerosis patients. Annals of Neurology. 2015 Feb 1;77(2):228-236. https://doi.org/10.1002/ana.24308
Kimbrough, Dorlan J. ; Sotirchos, Elias S. ; Wilson, James A. ; Al-Louzi, Omar ; Conger, Amy ; Conger, Darrel ; Frohman, Teresa C. ; Saidha, Shiv ; Green, Ari J. ; Frohman, Elliot ; Balcer, Laura J. ; Calabresi, Peter A. / Retinal damage and vision loss in African American multiple sclerosis patients. In: Annals of Neurology. 2015 ; Vol. 77, No. 2. pp. 228-236.
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