Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study

Deepthi Bannai, Paulo Lizano, Megan Kasetty, Olivia Lutz, Victor Zeng, Suraj Sarvode, Leo A. Kim, Scot Hill, Carol Tamminga, Brett Clementz, Elliot Gershon, Godfrey Pearlson, John B. Miller, Matcheri Keshavan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Studies utilizing optical coherence tomography (OCT) in psychosis have identified abnormalities in retinal cytoarchitecture. We aim to analyze retinal layer topography in psychosis and its correlation with clinical and imaging parameters. Macular retinal images were obtained via OCT in psychosis probands (n = 25) and healthy controls (HC, n = 15). Clinical, cognitive and structural MRI data were collected from participants. No thinning was noted for the retinal nerve fiber, ganglion cell or inner plexiform layers. We found significant thinning in the right inner temporal, right central, and left inner superior quadrants of the outer nuclear layer (ONL) in probands compared to HC. Thickening of the outer plexiform layer (OPL) was observed in the right inner temporal, left inner superior, and left inner temporal quadrants. The right inner temporal and left inner superior quadrants of both the OPL and ONL showed significant inverse correlations. Retinal pigment epithelium thinning correlated with worse mania symptoms, and thinning in the ONL was associated with worse cognitive function. ONL thinning was also associated with smaller total brain and white matter volume. Our findings suggest that outer retinal layers may provide additional insights into the pathophysiology of psychosis, possibly reflecting synaptic or inflammatory aberrations that lead to retinal pathologies.

Original languageEnglish (US)
Article number111061
JournalPsychiatry Research - Neuroimaging
Volume299
DOIs
StatePublished - May 30 2020

Keywords

  • Bipolar disorder
  • Cognition
  • Magnetic resonance imaging (MRI)
  • Optical coherence tomography (OCT)
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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