Retinoblastoma: Clinical and molecular perspectives

J. William Harbour

doi:10.1007/978-1-59745-458-2_23

Retinoblastoma: Clinical and molecular perspectives

J. William Harbour

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Retinoblastoma is a rare eye cancer that has been fundamental to the understanding of tumorigenesis. The RB gene was the first tumor suppressor gene to be discovered, and the Rb protein is targeted for inactivation in the vast majority of human cancers. This chapter reviews the clinical features of retinoblastoma and highlights the insights into molecular oncology that have resulted from study of the Rb tumor suppressor pathway.

Original language	English (US)
Title of host publication	The Molecular Basis of Human Cancer
Publisher	Springer New York
Pages	355-361
Number of pages	7
ISBN (Electronic)	9781597454582
ISBN (Print)	9781934115183
DOIs	https://doi.org/10.1007/978-1-59745-458-2_23
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Apoptosis
Cell cycle
Differentiation
Eye cancer
Retinoblastoma
Tumor suppressor

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-59745-458-2_23

Cite this

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AB - Retinoblastoma is a rare eye cancer that has been fundamental to the understanding of tumorigenesis. The RB gene was the first tumor suppressor gene to be discovered, and the Rb protein is targeted for inactivation in the vast majority of human cancers. This chapter reviews the clinical features of retinoblastoma and highlights the insights into molecular oncology that have resulted from study of the Rb tumor suppressor pathway.

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KW - Differentiation

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KW - Retinoblastoma

KW - Tumor suppressor

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Retinoblastoma: Clinical and molecular perspectives

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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