Retinoblastoma tumor suppressor: Where cancer meets the cell cycle

Erik S. Knudsen, Karen E. Knudsen

Research output: Contribution to journalShort survey

79 Scopus citations


The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

Original languageEnglish (US)
Pages (from-to)1271-1281
Number of pages11
JournalExperimental Biology and Medicine
Issue number7
StatePublished - Jan 1 2006



  • Cell cycle control
  • Cyclin
  • DNA replication
  • E2F
  • Mitosis
  • RB

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this