Retinoblastoma tumor suppressor: Where cancer meets the cell cycle

Erik S. Knudsen; Karen E. Knudsen

doi:10.1177/153537020623100713

Retinoblastoma tumor suppressor: Where cancer meets the cell cycle

Erik S. Knudsen, Karen E. Knudsen

Pathology

Research output: Contribution to journal › Short survey › peer-review

85 Scopus citations

Abstract

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

Original language	English (US)
Pages (from-to)	1271-1281
Number of pages	11
Journal	Experimental Biology and Medicine
Volume	231
Issue number	7
DOIs	https://doi.org/10.1177/153537020623100713
State	Published - 2006

Keywords

Cell cycle control
Cyclin
DNA replication
E2F
Mitosis
RB

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1177/153537020623100713

Cite this

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title = "Retinoblastoma tumor suppressor: Where cancer meets the cell cycle",

abstract = "The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.",

keywords = "Cell cycle control, Cyclin, DNA replication, E2F, Mitosis, RB",

author = "Knudsen, {Erik S.} and Knudsen, {Karen E.}",

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T2 - Where cancer meets the cell cycle

AU - Knudsen, Erik S.

AU - Knudsen, Karen E.

PY - 2006

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AB - The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

KW - Cell cycle control

KW - Cyclin

KW - DNA replication

KW - E2F

KW - Mitosis

KW - RB

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AN - SCOPUS:33745906528

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JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 7

ER -

Retinoblastoma tumor suppressor: Where cancer meets the cell cycle

Abstract

Keywords

ASJC Scopus subject areas

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