Retinoblastoma tumor suppressor

Where cancer meets the cell cycle

Erik S. Knudsen, Karen E. Knudsen

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

Original languageEnglish (US)
Pages (from-to)1271-1281
Number of pages11
JournalExperimental Biology and Medicine
Volume231
Issue number7
StatePublished - 2006

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Retinoblastoma
Cell Cycle Checkpoints
Tumor Suppressor Genes
Tumors
Cell Cycle
Cells
Neoplasms
Proteins
Genes

Keywords

  • Cell cycle control
  • Cyclin
  • DNA replication
  • E2F
  • Mitosis
  • RB

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Retinoblastoma tumor suppressor : Where cancer meets the cell cycle. / Knudsen, Erik S.; Knudsen, Karen E.

In: Experimental Biology and Medicine, Vol. 231, No. 7, 2006, p. 1271-1281.

Research output: Contribution to journalArticle

Knudsen, ES & Knudsen, KE 2006, 'Retinoblastoma tumor suppressor: Where cancer meets the cell cycle', Experimental Biology and Medicine, vol. 231, no. 7, pp. 1271-1281.
Knudsen, Erik S. ; Knudsen, Karen E. / Retinoblastoma tumor suppressor : Where cancer meets the cell cycle. In: Experimental Biology and Medicine. 2006 ; Vol. 231, No. 7. pp. 1271-1281.
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