Retinoblastoma tumor suppressor: Where cancer meets the cell cycle

Erik S. Knudsen, Karen E. Knudsen

Research output: Contribution to journalShort survey

80 Scopus citations

Abstract

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

Original languageEnglish (US)
Pages (from-to)1271-1281
Number of pages11
JournalExperimental Biology and Medicine
Volume231
Issue number7
DOIs
StatePublished - 2006

Keywords

  • Cell cycle control
  • Cyclin
  • DNA replication
  • E2F
  • Mitosis
  • RB

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Retinoblastoma tumor suppressor: Where cancer meets the cell cycle'. Together they form a unique fingerprint.

  • Cite this