Abstract
Tumorigenesis is a multistep process that involves sequential genetic alterations [1]. Preneoplastic cells must overcome their dependence on extrinsic mitogenic signals, evade apoptosis, prevent degradation of life-span-limiting telomeres, recruit vasculature, and acquire invasive properties to become malignant tumor cells [1].
Original language | English (US) |
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Title of host publication | Clinical Ophthalmic Oncology |
Subtitle of host publication | Retinoblastoma, Second Edition |
Publisher | Springer Berlin Heidelberg |
Pages | 61-68 |
Number of pages | 8 |
ISBN (Electronic) | 9783662434512 |
ISBN (Print) | 9783662434505 |
DOIs | |
State | Published - Jan 1 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine