Retinoic acid-induced alveolar cellular growth does not improve function after right pneumonectomy

D. Merrill Dane, Xiao Yan, Rahul M. Tamhane, Robert L. Johnson, Aaron S. Estrera, Deborah C. Hogg, Richard T. Hogg, Connie C W Hsia

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

To determine whether all-trans retinoic acid (RA) treatment enhances lung function during compensatory lung growth in fully mature animals, adult male dogs (n = 4) received 2 mg·kg-1·day-1 po RA 4 days/wk beginning the day after right pneumonectomy (R-PNX, 55-58% resection). Litter-matched male R-PNX controls (n = 4) received placebo. After 3 mo, transpulmonary pressure (TPP)-lung volume relationship, diffusing capacities for carbon monoxide and nitric oxide, cardiac output, and septal volume (V tiss-RB) were measured under anesthesia by a rebreathing technique at two lung volumes. Lung air and tissue volumes (Vair-CT and V tiss-CT) were also measured from high-resolution computerized tomographic (CT) scans at a constant TPP. In RA-treated dogs compared with controls, TPP-lung volume relationships were similar. Diffusing capacities for carbon monoxide and nitric oxide were significantly impaired at a lower lung volume but similar at a high lung volume. Whereas Vtiss-RB was significantly lower at both lung volumes in RA-treated animals, V air-CT and Vtiss-CT were not different between groups; results suggest uneven distribution of ventilation consistent with distortion of alveolar geometry and/or altered small airway function induced by RA. We conclude that RA does not improve resting pulmonary function during the early months after R-PNX despite histological evidence of its action in enhancing alveolar cellular growth in the remaining lung.

Original languageEnglish (US)
Pages (from-to)1090-1096
Number of pages7
JournalJournal of applied physiology
Volume96
Issue number3
DOIs
StatePublished - Mar 1 2004

Keywords

  • Carbon monoxide diffusing capacity
  • Compensatory lung growth
  • Computerized tomographic scan
  • Dog
  • Nitric oxide diffusing capacity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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