Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

Steven A. Kliewer, Kazuhiko Umesono, David J. Mangelsdorf, Ronald M. Evans

Research output: Contribution to journalArticle

1163 Citations (Scopus)

Abstract

CELLULAR responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct1 families of receptors: the retinoic acid receptors (RAR)2,3 and the retinoid X receptors (RXR)1. Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. RAR and RXR have a high degree of cooperativity in binding to target DNA, consistent with previous reports indicating that the binding of either RAR or RXR to their cognate response elements is enhanced by factors present in nuclear extracts4,5. RXR also interacts directly with and enhances the binding of nuclear receptors conferring responsiveness to vitamin D3 and thyroid hormone T3; the DNA-binding activities of these receptors are also stimulated by the presence of nuclear extracts6-9. Together these data indicate that RXR has a central role in multiple hormonal signalling pathways.

Original languageEnglish (US)
Pages (from-to)446-449
Number of pages4
JournalNature
Volume355
Issue number6359
StatePublished - Jan 30 1992

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Retinoid X Receptors
Cholecalciferol
Cytoplasmic and Nuclear Receptors
Tretinoin
Thyroid Hormones
Retinoic Acid Receptors
DNA
Response Elements
Triiodothyronine
Proteins

ASJC Scopus subject areas

  • General

Cite this

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. / Kliewer, Steven A.; Umesono, Kazuhiko; Mangelsdorf, David J.; Evans, Ronald M.

In: Nature, Vol. 355, No. 6359, 30.01.1992, p. 446-449.

Research output: Contribution to journalArticle

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