RETRACTED ARTICLE: Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum

Suresh Regonda, Krutarth Trivedi, Ruhai Tian, Lisa Spurgin, Serena Green, Jiahuan Ding, Jinming Gao, Walter Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we demonstrate the use of multiple Si nanochannel (NC) or nanograting (NG) instead of the conventional single channel or nanowire design in biosensors can significantly reduce device to device variation, and improve device performance (higher current, higher ON/OFF ratio, smaller SS, lower Vt) in buffer solution. NG devices also result in higher sensor stability (repeated sensing over tens of hours) in buffer and human serum. We believe such improvements are due to reduced discrete dopant fluctuation and biochemical noise in the solution. The improved devices allow us to sense pH linearly with 3-aminopropyltriethoxysilane (APTES) coated devices, and to selectively detect insulin with limit of detection down to 10fM in both buffer solution and human serum without pre-purification.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Conference on Nanotechnology
PublisherIEEE Computer Society
Pages621-624
Number of pages4
ISBN (Print)9781457715143
DOIs
StatePublished - 2011
Event2011 11th IEEE International Conference on Nanotechnology, NANO 2011 - Portland, OR, United States
Duration: Aug 15 2011Aug 19 2011

Other

Other2011 11th IEEE International Conference on Nanotechnology, NANO 2011
CountryUnited States
CityPortland, OR
Period8/15/118/19/11

Fingerprint

insulin
Insulin
Field effect transistors
serums
Buffers
field effect transistors
buffers
Biosensors
Nanowires
Purification
Doping (additives)
Sensors
bioinstrumentation
purification
high current
nanowires
sensors

Keywords

  • bio-FETs
  • biosensor
  • Insulin
  • pH Sensing
  • Si nanograting

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

Cite this

Regonda, S., Trivedi, K., Tian, R., Spurgin, L., Green, S., Ding, J., ... Hu, W. (2011). RETRACTED ARTICLE: Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum. In Proceedings of the IEEE Conference on Nanotechnology (pp. 621-624). [6144453] IEEE Computer Society. https://doi.org/10.1109/NANO.2011.6144453

RETRACTED ARTICLE : Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum. / Regonda, Suresh; Trivedi, Krutarth; Tian, Ruhai; Spurgin, Lisa; Green, Serena; Ding, Jiahuan; Gao, Jinming; Hu, Walter.

Proceedings of the IEEE Conference on Nanotechnology. IEEE Computer Society, 2011. p. 621-624 6144453.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Regonda, S, Trivedi, K, Tian, R, Spurgin, L, Green, S, Ding, J, Gao, J & Hu, W 2011, RETRACTED ARTICLE: Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum. in Proceedings of the IEEE Conference on Nanotechnology., 6144453, IEEE Computer Society, pp. 621-624, 2011 11th IEEE International Conference on Nanotechnology, NANO 2011, Portland, OR, United States, 8/15/11. https://doi.org/10.1109/NANO.2011.6144453
Regonda S, Trivedi K, Tian R, Spurgin L, Green S, Ding J et al. RETRACTED ARTICLE: Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum. In Proceedings of the IEEE Conference on Nanotechnology. IEEE Computer Society. 2011. p. 621-624. 6144453 https://doi.org/10.1109/NANO.2011.6144453
Regonda, Suresh ; Trivedi, Krutarth ; Tian, Ruhai ; Spurgin, Lisa ; Green, Serena ; Ding, Jiahuan ; Gao, Jinming ; Hu, Walter. / RETRACTED ARTICLE : Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum. Proceedings of the IEEE Conference on Nanotechnology. IEEE Computer Society, 2011. pp. 621-624
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