RETRACTED ARTICLE: Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum

Suresh Regonda, Krutarth Trivedi, Ruhai Tian, Lisa Spurgin, Serena Green, Jiahuan Ding, Jinming Gao, Walter Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we demonstrate the use of multiple Si nanochannel (NC) or nanograting (NG) instead of the conventional single channel or nanowire design in biosensors can significantly reduce device to device variation, and improve device performance (higher current, higher ON/OFF ratio, smaller SS, lower Vt) in buffer solution. NG devices also result in higher sensor stability (repeated sensing over tens of hours) in buffer and human serum. We believe such improvements are due to reduced discrete dopant fluctuation and biochemical noise in the solution. The improved devices allow us to sense pH linearly with 3-aminopropyltriethoxysilane (APTES) coated devices, and to selectively detect insulin with limit of detection down to 10fM in both buffer solution and human serum without pre-purification.

Original languageEnglish (US)
Title of host publication2011 11th IEEE International Conference on Nanotechnology, NANO 2011
PublisherIEEE Computer Society
Pages621-624
Number of pages4
ISBN (Print)9781457715143
DOIs
StatePublished - 2011
Event2011 11th IEEE International Conference on Nanotechnology, NANO 2011 - Portland, OR, United States
Duration: Aug 15 2011Aug 19 2011

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Other

Other2011 11th IEEE International Conference on Nanotechnology, NANO 2011
CountryUnited States
CityPortland, OR
Period8/15/118/19/11

Keywords

  • Insulin
  • Si nanograting
  • bio-FETs
  • biosensor
  • pH Sensing

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'RETRACTED ARTICLE: Si multi-nanochannel FETs to improve device uniformity/stability and detection of 10 fM insulin in serum'. Together they form a unique fingerprint.

Cite this