Ürogenital sistem sarkomlarinin retrospektif analizi

Translated title of the contribution: Retrospective analysis of sarcomas of the urogenital system

Engin Kandirali, Öner Şanli, Fikret Erdemir, Faruk Özcan, Tarik Esen, Murat Tunç

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Introduction: Sarcomas account for only about 1% of all malignant tumors. Less than 5% or soft tissue sarcomas arise from the genitourinary tract, accounting for only 1 to 2% of all malignant genitourinary tumors. Because of the rarity of these tumors, the basic problem in the management of these tumors is the lack of a uniform approach for staging and treatment. Although sarcomas arise from different organs in the genitourinary tract and compromise different histopathological features, the main treatment modality is surgical resection of the tumor. The aim of this study is to evaluate the clinical and pathological features and prognosis of genitourinary tumors treated in our clinic. Materials and methods: Between 1997 and 2003, after excluding the gynecological sarcomas, a total of 15 genitourinary sarcomas were treated in our clinic. All patients were evaluated with a detailed medical history, physical examination, multiple serum analyses and imaging modalities such as ultrasonography, computed tomography and magnetic resonance imaging if needed. Thus, tru-cut biopsy was performed if indicated. For all patients, the primary treatment modality was open surgical resection. In addition to surgery, some of these patients also received adjuvant radiation therapy and/or chemotherapy. For staging, Memorial Sloan-Kettering Cancer Center soft tissue sarcoma staging system was used. Post-operative follow-up was done in regular intervals. Results: The mean age of patients was 50.4 ±14.7 (16-69) years and the mean tumor size was 8±3.5 cm. The chief complaints (one or more) of these patients were hematuria in 9, flank pain in 7, weight loss in 6, abdominal pain in 5, abdominal mass in 4, lower urinary tract symptoms in 3. Five bladder, six kidney, three retroperitoneal and one prostate sarcoma were detected in three women and 12 men. Histopathology of these tumors were leiomyosarcomas in nine, liposarcomas in three, rhabdomyosarcomas in two, malignant fibrous histiocytoma in one of the patients. Of these tumors, three were low grade and 12 were high grade. All patients except one underwent open surgical resection of the tumors. For five patients surgical resection was the only treatment modality, while eleven patients received adjuvant chemotherapy and/or radiotherapy after surgery. After a follow-up of 10.2±4.7 (3-20) months, overall survival rate was found to be 20% (3/15). Conclusion: Genitourinary sarcomas are a rare group of tumors with a generally poor prognosis. Complete surgical resection is still the mainstay of treatment. Further large scale studies, are needed to better understand the major prognostic determinants of these tumors and to identify specific treatments.

Translated title of the contributionRetrospective analysis of sarcomas of the urogenital system
Original languageTurkish
Pages (from-to)49-54
Number of pages6
JournalTurk Uroloji Dergisi
Volume31
Issue number1
StatePublished - Jun 2 2005

Keywords

  • Prognosis
  • Sarcoma
  • Survival
  • Urogenital tumors

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Kandirali, E., Şanli, Ö., Erdemir, F., Özcan, F., Esen, T., & Tunç, M. (2005). Ürogenital sistem sarkomlarinin retrospektif analizi. Turk Uroloji Dergisi, 31(1), 49-54.