Retrospective cohort study of surgical staging for ovarian low malignant potential tumors

Shana N. Wingo, Lynne M. Knowles, Kelley S. Carrick, David S. Miller, John O. Schorge

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors. Study design: This was a retrospective cohort study of all ovarian low malignant potential tumors that were diagnosed by frozen section or final pathologic review from 2003 to 2005. Results: Twenty-two of 32 patients (69%) were staged surgically. Sixteen low malignant potential tumors were stage I by final pathologic review, and 4 tumors were upstaged to stage II-III disease. Two other patients had early invasive ovarian carcinoma, despite a frozen section that suggested low malignant potential; 1 patient received adjuvant chemotherapy. The tumors of 10 women (31%) were unstaged. Frozen section suspicion of low malignant potential (P = .003) and surgery by a gynecologic oncologist (P < .001) correlated with staging. Preoperative CA-125, intraoperative blood loss, and postoperative hospitalization were increased in patients with staged disease (each P < .05). Two women who underwent fertility-sparing surgery experienced a recurrence in the contralateral ovary. Conclusion: Surgical staging of ovarian low malignant potential tumors has limited value for most patients, unless invasive carcinoma is diagnosed by final pathologic review.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume194
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Cohort Studies
Retrospective Studies
Frozen Sections
Neoplasms
Carcinoma
Postoperative Hemorrhage
Gynecologic Surgical Procedures
Adjuvant Chemotherapy
Fertility
Ovary
Hospitalization
Recurrence

Keywords

  • Borderline ovarian tumors
  • Ovarian low malignant potential tumors
  • Surgical staging

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Retrospective cohort study of surgical staging for ovarian low malignant potential tumors. / Wingo, Shana N.; Knowles, Lynne M.; Carrick, Kelley S.; Miller, David S.; Schorge, John O.

In: American Journal of Obstetrics and Gynecology, Vol. 194, No. 5, 05.2006.

Research output: Contribution to journalArticle

@article{ea5975ce98954968807738d462186af7,
title = "Retrospective cohort study of surgical staging for ovarian low malignant potential tumors",
abstract = "Objective: The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors. Study design: This was a retrospective cohort study of all ovarian low malignant potential tumors that were diagnosed by frozen section or final pathologic review from 2003 to 2005. Results: Twenty-two of 32 patients (69{\%}) were staged surgically. Sixteen low malignant potential tumors were stage I by final pathologic review, and 4 tumors were upstaged to stage II-III disease. Two other patients had early invasive ovarian carcinoma, despite a frozen section that suggested low malignant potential; 1 patient received adjuvant chemotherapy. The tumors of 10 women (31{\%}) were unstaged. Frozen section suspicion of low malignant potential (P = .003) and surgery by a gynecologic oncologist (P < .001) correlated with staging. Preoperative CA-125, intraoperative blood loss, and postoperative hospitalization were increased in patients with staged disease (each P < .05). Two women who underwent fertility-sparing surgery experienced a recurrence in the contralateral ovary. Conclusion: Surgical staging of ovarian low malignant potential tumors has limited value for most patients, unless invasive carcinoma is diagnosed by final pathologic review.",
keywords = "Borderline ovarian tumors, Ovarian low malignant potential tumors, Surgical staging",
author = "Wingo, {Shana N.} and Knowles, {Lynne M.} and Carrick, {Kelley S.} and Miller, {David S.} and Schorge, {John O.}",
year = "2006",
month = "5",
doi = "10.1016/j.ajog.2005.11.033",
language = "English (US)",
volume = "194",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Retrospective cohort study of surgical staging for ovarian low malignant potential tumors

AU - Wingo, Shana N.

AU - Knowles, Lynne M.

AU - Carrick, Kelley S.

AU - Miller, David S.

AU - Schorge, John O.

PY - 2006/5

Y1 - 2006/5

N2 - Objective: The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors. Study design: This was a retrospective cohort study of all ovarian low malignant potential tumors that were diagnosed by frozen section or final pathologic review from 2003 to 2005. Results: Twenty-two of 32 patients (69%) were staged surgically. Sixteen low malignant potential tumors were stage I by final pathologic review, and 4 tumors were upstaged to stage II-III disease. Two other patients had early invasive ovarian carcinoma, despite a frozen section that suggested low malignant potential; 1 patient received adjuvant chemotherapy. The tumors of 10 women (31%) were unstaged. Frozen section suspicion of low malignant potential (P = .003) and surgery by a gynecologic oncologist (P < .001) correlated with staging. Preoperative CA-125, intraoperative blood loss, and postoperative hospitalization were increased in patients with staged disease (each P < .05). Two women who underwent fertility-sparing surgery experienced a recurrence in the contralateral ovary. Conclusion: Surgical staging of ovarian low malignant potential tumors has limited value for most patients, unless invasive carcinoma is diagnosed by final pathologic review.

AB - Objective: The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors. Study design: This was a retrospective cohort study of all ovarian low malignant potential tumors that were diagnosed by frozen section or final pathologic review from 2003 to 2005. Results: Twenty-two of 32 patients (69%) were staged surgically. Sixteen low malignant potential tumors were stage I by final pathologic review, and 4 tumors were upstaged to stage II-III disease. Two other patients had early invasive ovarian carcinoma, despite a frozen section that suggested low malignant potential; 1 patient received adjuvant chemotherapy. The tumors of 10 women (31%) were unstaged. Frozen section suspicion of low malignant potential (P = .003) and surgery by a gynecologic oncologist (P < .001) correlated with staging. Preoperative CA-125, intraoperative blood loss, and postoperative hospitalization were increased in patients with staged disease (each P < .05). Two women who underwent fertility-sparing surgery experienced a recurrence in the contralateral ovary. Conclusion: Surgical staging of ovarian low malignant potential tumors has limited value for most patients, unless invasive carcinoma is diagnosed by final pathologic review.

KW - Borderline ovarian tumors

KW - Ovarian low malignant potential tumors

KW - Surgical staging

UR - http://www.scopus.com/inward/record.url?scp=33646088124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646088124&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2005.11.033

DO - 10.1016/j.ajog.2005.11.033

M3 - Article

C2 - 16647891

AN - SCOPUS:33646088124

VL - 194

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -