TY - JOUR
T1 - Retrospective cost analysis of gemcitabine in combination with cisplatin in non-small cell lung cancer compared to other combination therapies in Europe
AU - Schiller, Joan
AU - Tilden, Dominic
AU - Aristides, Michael
AU - Lees, Michael
AU - Kielhorn, Adrian
AU - Maniadakis, Nikos
AU - Bhalla, Shkun
PY - 2004/1
Y1 - 2004/1
N2 - In two recent randomised trials, gemcitabine plus cisplatin (Gem/Cis) was found to be at least as effective as vinorelbine plus cisplatin (Vin/Cis), paclitaxel plus cisplatin (Pac/Cis), paclitaxel plus carboplatin (Pac/Carbo), or docetaxel plus cisplatin (Doc/Cis) in patients with advanced non-small cell lung cancer (NSCLC). In cost-minimisation analyses of these studies from the perspectives of the national health services of five European countries (France, Germany, Italy, Spain, UK), Gem/Cis was associated with lower average treatment-related costs than Vin/Cis, Pac/Cis, and Pac/Carbo, and similar or lower costs than Doc/Cis. The incremental cost savings per patient of Gem/Cis compared to Vin/Cis ranged from € 827 to € 2055 per patient and from € 1616 to € 5342 compared to the paclitaxel-containing regimens. Overall, results were generally similar between countries, and were robust to univariate sensitivity analyses. Although differences in healthcare systems mean that the results may not be generalisable to all countries/settings, these results provide an economic rationale for the use of Gem/Cis as a first-line treatment option in Europe for patients with NSCLC.
AB - In two recent randomised trials, gemcitabine plus cisplatin (Gem/Cis) was found to be at least as effective as vinorelbine plus cisplatin (Vin/Cis), paclitaxel plus cisplatin (Pac/Cis), paclitaxel plus carboplatin (Pac/Carbo), or docetaxel plus cisplatin (Doc/Cis) in patients with advanced non-small cell lung cancer (NSCLC). In cost-minimisation analyses of these studies from the perspectives of the national health services of five European countries (France, Germany, Italy, Spain, UK), Gem/Cis was associated with lower average treatment-related costs than Vin/Cis, Pac/Cis, and Pac/Carbo, and similar or lower costs than Doc/Cis. The incremental cost savings per patient of Gem/Cis compared to Vin/Cis ranged from € 827 to € 2055 per patient and from € 1616 to € 5342 compared to the paclitaxel-containing regimens. Overall, results were generally similar between countries, and were robust to univariate sensitivity analyses. Although differences in healthcare systems mean that the results may not be generalisable to all countries/settings, these results provide an economic rationale for the use of Gem/Cis as a first-line treatment option in Europe for patients with NSCLC.
KW - Chemotherapy
KW - Cisplatin
KW - Cost-minimisation analysis
KW - Gemcitabine
KW - Non-small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=0347931813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347931813&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2003.06.003
DO - 10.1016/j.lungcan.2003.06.003
M3 - Article
C2 - 14698544
AN - SCOPUS:0347931813
SN - 0169-5002
VL - 43
SP - 101
EP - 112
JO - Lung Cancer
JF - Lung Cancer
IS - 1
ER -