Retrospective evaluation of pediatric cranio-spinal axis irradiation plans with the Hi-ART tomotherapy system

José A. Peñagarícano, Yulong Yan, Peter Corry, Eduardo Moros, Vaneerat Ratanatharathorn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Helical tomotherapy (HT) can be used for the delivery of cranio-spinal axis irradiation (CSAI) without the need for beam matching of conventional linac-based external beam irradiation. The aim of this study is to retrospectively evaluate HT plans used for treatment in nine patients treated with CSAI. Helical tomotherapy cranio-spinal axis irradiation (HT-CSAI) plans were created for each patient. Average length along the cranio-spinal axis of the PTV was 65.6 cm with a range between 53 and 74 cm. Treatment planning optimization and plan evaluation parameters were obtained from the HT planning station for each of the nine patients. PTV coverage by the 95% isodose surface ranged between 98.0 to 100.0% for all nine patients. The clinically acceptable dose variation within the PTV or tolerance range was between 0.7 and 2.5% for all nine patients. Doses to the organs at risk were clinically acceptable. An increasing length along the longitudinal axis of the PTV did not consistently increase the beam-on time indicating that using a larger jaw width had a greater impact on treatment time. With a larger jaw width it is possible to substantially reduce the normalized beam-on treatment time without compromising plan quality and sparing of organs at risk. By using a larger jaw width or lower modulation factor or both, normalized beam-on times were decreased by up to 61% as compared to the other evaluated treatment plans. From the nine cases reported in this study the minimum beam-on time was achieved with a jaw width of 5.0 cm, pitch of 0.287 and a modulation factor of 2.0. Large and long cylindrical volumes can be effectively treated with helical tomotherapy with both clinically acceptable dose distribution and beam-on time.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalTechnology in Cancer Research and Treatment
Volume6
Issue number4
StatePublished - Aug 2007

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Intensity-Modulated Radiotherapy
Pediatrics
Jaw
Organs at Risk
Therapeutics

Keywords

  • Beam-on time
  • Cranio-spinal irradiation
  • Helical tomotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Retrospective evaluation of pediatric cranio-spinal axis irradiation plans with the Hi-ART tomotherapy system. / Peñagarícano, José A.; Yan, Yulong; Corry, Peter; Moros, Eduardo; Ratanatharathorn, Vaneerat.

In: Technology in Cancer Research and Treatment, Vol. 6, No. 4, 08.2007, p. 355-360.

Research output: Contribution to journalArticle

Peñagarícano, José A. ; Yan, Yulong ; Corry, Peter ; Moros, Eduardo ; Ratanatharathorn, Vaneerat. / Retrospective evaluation of pediatric cranio-spinal axis irradiation plans with the Hi-ART tomotherapy system. In: Technology in Cancer Research and Treatment. 2007 ; Vol. 6, No. 4. pp. 355-360.
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