Retrospective study of venous thromboembolic and intracerebral hemorrhagic events in glioblastoma patients

Edward Pan, Jerry S. Tsai, Susan B. Mitchell

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Background: Venous thromboembolism (VTE) is a common complication in glioblastoma (GB) patients. Patients and Methods: A retrospective medical record review identified 294 GB patients with VTE or ICH; 146 patients with sufficient treatment records were included. Treatment approaches for GB patients who developed VTE were also reported. Results: Of 146 patients, 41 (28%) developed VTE and 3 (2%) developed ICH. Seven (17%) of the 41 VTE patients developed recurrent VTE. Practice patterns for VTE treatment varied widely. Patient demographics were not significantly associated with VTE development. Conclusion: Despite a low incidence of ICH, even with anticoagulation therapy, physicians are reluctant to administer anticoagulants to GB patients with VTE. The optimum treatment for GB patients with VTE has not been established; however, the benefits of anticoagulation therapy may outweigh the risks of ICH. A prospective clinical trial to evaluate the potential benefits for deep venous thrombosis prophylaxis in GB patients is warranted.

Original languageEnglish (US)
Pages (from-to)4309-4313
Number of pages5
JournalAnticancer Research
Volume29
Issue number10
StatePublished - Oct 1 2009

Keywords

  • Anticoagulant
  • Cerebral hemorrhage
  • Glioblastoma
  • Pulmonary embolism
  • Venous glioblastoma
  • Venous thromboembolism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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